The Structure of the Corpus Callosum in Obsessive Compulsive Disorder
It's normal to go back and make sure you locked your car, or that you turned off the stove after you leave the house. However if you suffer from Obsessive-Compulsive disorder, thoughts like this become more like rituals and can interfere with your daily life. OCD is an anxiety disorder in which people have repeated thoughts, feelings, ideas, sensations (obsessions), or behaviors that make them feel driven to do something. (compulsions) This disease should be researched in order to elucidate the causes of OCD. If the causes of it can be found then a cure could be found in turn. Introduction:
The corpus callosum (CC) is the part of the brain that connects the two hemispheres. The CC actually affects the entire brain because it regulates communication between the two hemispheres. Some of the functions of the CC are modulating attention and inhibiting neural activity in the cortex, both of these processes are dysfunctional in OCD, thus it was hypothesized that the CC is a key factor in OCD. Abnormalities in the CC have only received minimal attention in the context of OCD, a study was done in the 1990's that only found minimal size differences between patients with OCD and control patients. The latest work done on the CC in regards to OCD also found minimal differences between the thickness of the posterior end of the corpus callosum. Altogether the studies conducted in the past have yielded inconsistent results, due to the lack of sample size, as well as the different imaging modalities. The main goal of this study was to investigate the structural differences in the CC's of a relatively large sample size through 2 different MRI techniques. One technique was the manual tracing of the CC, another was an automatic procedure that indicates the level of white matter (WM)in the CC. Methods:
30 patients that were diagnosed with OCD, and 30 healthy...
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