Hemophilia Benefited Coagulation Disorder

Hemophilia is the most common inherited coagulation disorder. Although hemophilia is commonly inherited, it can also occur due to a spontaneous mutation. Hemophilia A is an X-linked, recessive disorder caused by a deficiency of Factor VIII. Hemophilia can be severe, moderate, or mild. Individuals diagnosed with severe hemophilia A are typically diagnosed early in life, prior to age two. This is diagnosed particularly following episodes of bleeding from mouth injuries and bumps on the head. Spontaneous bleeding may occur as well as prolonged bleeding from injuries. Roughly five episodes of spontaneous or prolonged bleeding can occur each month. In cases of moderate hemophilia A, individuals have delayed clotting after minor injuries,
Serious, life-threatening complications can occur from bleeding into the joint, muscle, brain, or internal organs. According to Jovandaric and Jesic (2015), the absence of a positive family history can delay diagnosis and treatment.
Hemophilia A is an X-linked, recessive disorder caused by a deficiency of Factor VIII. Because this is an X-linked disorder, this nearly always affects males. Females who have the hemophilia A gene mutation are therefore carriers. Carriers typically have no symptoms. Carriers have a 50 percent chance of transmitting FVIII in each pregnancy. When a father has hemophilia A, his male offspring will not be affected by the disorder, but all of his daughters will be carriers. When a male child is the first case of hemophilia A in the family, this may be inherited from the mother who may be a carrier or a mutation that occurred by chance. The gene for Hemophilia A, or FVIII, is located on the X chromosome, long arm, in the Xq28 region (Zaiden, 2016). This is an unusually large gene and when mature contains 2332 amino acids. According to Zaiden (2016), homologous recombination of the factor VIII
With hemophilia clotting factors vary widely. If the clotting factor is mildly reduced, prolonged bleeding usually occurs after surgery or trauma. If the clotting factor is severely reduced, bleeding can occur spontaneously. Those affected by hemophilia A may experience prolonged bleeding following cuts or injuries, vaccination or injections, and following dental work or surgery. Bruises may occur from unknown causes. Blood could be apparent in stool or urine and nosebleeds are common without a particular cause. Emergency symptoms of hemophilia include sudden pain, swelling, or warmth of large joints, prolonged headache, excessive vomiting, extreme