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Health Research
Health research methodology: A guide for training in research methods

HEALTH RESEARCH METHODOLOGY
A Guide for Training in Research Methods
Second Edition

WORLD HEALTH ORGANIZATION
Regional Office for the Western Pacific
Manila, 2001

i

CONTENTS
Foreword

v

Introduction

vii

Acknowledgements

ix

Chapter 1: Introduction to research

1

Chapter 2: Research strategies and design

11

Chapter 3: Descriptive epidemiological studies and clinical trials

43

Chapter 4: Experimental studies and clinical trials

55

Chapter 5: Sampling methods and sampling size

71

Chapter 6: Bias and confounding

85

Chapter 7: Basic risk measurement

97

Chapter 8: Tests of significance

107

Chapter 9: Association and causation

125

Chapter 10: Ethical aspects of health research

141

Chapter 11: Construction of a research proposal

147

Annexes:
Annex 1:

Questionnaire design

169

Annex 2:

Descriptive statistics: Table, graphs, and charts

187

Annex 3:

Organization of a workshop on research methods in health sciences

211

Index

232

Health research methodology: A guide for training in research methods

WHO Library Cataloguing in Publication Data
Health Research Methodology: A guide for training in research methods. Second
Edition.
1. Health services research - methods.
2. Research design.
I. World Health Organization. Regional Office for the Western Pacific
ISBN 92 9061 157 X

The World Health Organization welcomes requests for permission to reproduce or translate its publications, in part or in full. Applications and enquiries should be addressed to the Office of Publications, World Health Organization, Geneva, Switzerland or to the
Regional Office for the Western Pacific, Manila, Philippines, which will be glad to provide the latest information on any changes made to the text, plans for new editions, and reprints and translations already available.
© World Health



References: University Medical Center, 1983. Cushieri A., Baker P.R. Introduction to research in medical sciences. Edinburgh, Churchill Livingstone, 1977. Marks R. Designing a research project. Belmont, CA, Lifetime Learning Publications, 1982.

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