HFE Genetic Synthesis

The HFE gene is autosomal recessive, meaning the trait for the disease must be in both parents for the disease to continue to their children. If only one of the mutated genes are in possession they become a carrier for the next generation. The gene HFE is responsible for regulating the amounts of iron in the bloodstream, moreover the amount of iron a human can absorb from the foods people eat. In addition, a protein called hepcidin has the same position as HFE, which manages iron metabolism. Deficiency of hepcidin is likely to cause most of the types of hemochromatosis. The mutation C282Y (Cys282Tyr) affects the HFE gene and is one of the most frequent causes for hemochromatosis. Addition to C282Y the mutation H63D (His63Asp) found on chromosome