Another difference between the two paintings is the use of nudity. In "Les Demoiselles", Picasso shows a depiction of five women in very distorted forms yet all of them are portrayed in the nude. This could be deciphered in many ways but the most common interpretation is that they are prostitutes. In "Guernica" there is very little human depiction at all yet what depiction there is, is not so brazenly displayed. The human forms seen in "Les Demoiselles" is either no more than a head or facial view or the body itself is covered or distorted beyond anything recognizable.
The feelings conveyed by each of the paintings is yet another difference. In "Les Demoiselles" one seems to be overcome with a feeling of serenity and peace at the same time a sense of eroticism emits from within the painting. The feeling Picasso is trying to draw from the viewer seems almost blatantly clear. When looking into "Guernica", feelings of death and danger and sheer utter terror seem to seep out of the various lines and scenes of the painting. "Guernica" seems to me to be a very angry painting full of hidden images and themes. It is very secretive in nature, almost as if Picasso did not want anyone to know the true meaning behind this work of art.
The specific political statement Picasso is trying to make within "Guernica" most definitely caused him to change his approach to the style of painting he was doing at the time.