Gotu Kola Research Paper

Aloe (Aloe vera) is a major and traditional medicinal plant under family of Liliaceae. Aloe consumed externally and internally as well. It is used externally to treat several skin burn conditions, sunburn and poison oak, infections, and eczema. It is confirm that juice from Aloe vera ease pain and decrease inflammation. It has antiseptic and antibiotic properties in treating cuts and abrasions. Aloe juice used to treat people with ulcerative colitis, an inflammatory bowel disease. Moreover it acts as a remedy for coughs, wounds, ulcers, headaches, arthritis, gastritis, diabetes, cancer. It acts as a immunity booster in patients with immune-system deficiencies, and support in many additional conditions while taken internally. Though, the general
Its parts utilized for medicinal purposes are its leaves along with the petioles. There are numerous common names in usage for this plant in different parts of the world but in Sri Lanka, the most familiar name is Gotu kola. It is a slender, creeping perennial with long creeping runners. Gotu kola is found in most tropical and subtropical countries, grow up in swampy areas, comprising parts of India, Pakistan, Sri Lanka, Madagascar, South Africa and South pacific and Eastern Europe (Mahmood et al., 2015). There is a broad range of pharmacological actions found in C. asiatica comprising memory and learning enhancing activity, Antioxidant activity, Antibacterial activity, Antifungal activity , Antiviral activity , Anti-protozoal activity , Anti-filarial activity , Antiulcer activity, Anti-diabetic activity , Anti-inflammatory activity , Cytotoxic and anti-tumour activity , Neuro-protective activity, Cardio-protective activity , Skin protective activity , Radio-protective activity , Immuno-modulatory effect , Wound healing effect , anti-anxiety activity, attenuating effect in age–related decline in cognitive function and mood disorder, antidepressant effect, wound healing activity etc (Seevaratnam et al, 2012). Analgesic and anti-inflammatory effects have related with glycosides and terpenes. Luteolin has been described to own major antiallergic and anti-inflammatory effect. Some glycosides have effective in inhibitory activities against a wide range of enzymes like protein kinase C, protein tyrosine kinase, phospholipase A2. Certain glycosides effectually inhibit prostaglandins, a collection of pro-inflammatory signalling molecules. This is chiefly due to inhibition of certain enzymes participating in prostaglandin biosynthesis such as lipoxygenase, phospholipase and cycloxygenase. Inhibition of these enzymes by glycosides inhibits the inflammatory process (George and Joseph, 2010). Below table 2 shows the chemical