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Glutathione Peroxidase And Anthracene Case Study

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Glutathione Peroxidase And Anthracene Case Study
Abstract
The effect of lycopene on 7,12 dimethyl benz(a)anthracene (DMBA) induced experimental breast cancer was investigated in female Sprague Dawley rats. Histopathological examination revealed the formation of tumor and angiogenesis in DMBA-induced rats and these abnormal changes were ameliorated by treatment with lycopene. The protective effect of lycopene was inherent to the increase of the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx)) and glutathione (GSH). Flux cytometry and gene expression analyses indicated that lycopene inhibits breast tumorigenesis by promoting apoptosis in mammary tissue through the mediation of pro- and anti-apoptotic biomarkers. Further analyses suggested that the antitumor
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