Growth and Nutritional Status of Children with Epilepsy on Ketogenic Diet: A Preliminary Prospective Long-term Study Yeou-mei Christiana Liu1 (email@example.com), Elke Sengmueller2, and Rosalind Curtis1 1The Hospital for Sick Children, Toronto and Bloorview Macmillan Children’s Centre, Toronto and 2Ketogenic Diet Program, Bloorview Site, Bloorview Macmillan Children’s Centre, 25 Buchan Court, Willowdale, Ontario, Canada M2J 4S9 Background: The ketogenic diet is one of the most effective therapies for intractable seizure for the paediatric population. Although the beneficial effects of the diet are well-known, potential suboptimal growth and nutritional risks of the diet have been evaluated by limited research articles only. The 4-month earlier study of the authors has demonstrated that the nutritional status and linear growth of children on the ketogenic diet can be maintained. Objective: Investigate the impact of two types of ketogenic diets on children’s growth and nutritional status over a longer period. Methodology: Participants included 19 children on the classic ketogenic diet and 6 children on the MCT (medium-chain trigylceride) ketogenic diet. All children had failed at least two anticonvulsant. Weight, height, and biochemical indices were obtained at pre-diet, 6 months, 12 months, 18 months, and 24 months of the study. Results: In classic ketogenic diet groups with 19 participants, there were, on average, 2.4 cm (2.6%) of height increase and 0.9 kg (0.05%) of weight increase at 6 months on the diet; 5.3 cm (6.2%) of height increase and 1.2 kg (0.1%) of weight increase at 12 months with 11 (58%) participants; 4.6 cm (4.7%) of height increase and 2.5 kg (0.17%) of weight increase at 18 months with 5 (26%) participants; and 8.1 cm (8%) of height increase and 3.8 kg (0.24%) of weight increase at 24 months with 2 (11%) participants. In MCT ketogenic diet group with 6 participants, there were, on average, 1.3 cm (1.3%) of height increase...
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