Fmr1 Rat Training
Hello Dr Buxbaum,
Below is my weekly update for this week from 24th Aug '16 to 26th Aug '16.
1) FMR1 5-choice training:
- At the end of the 9th week of the Fmr1 rat training, we have 1 rat that finished the challenge trials running on reminder S8b schedules. It is a male wild type that performed with more than 75% accuracy with fewer than 10% omissions. The second rat was run on baseline schedule today and it performed exceptionally well with 88% accuracy and 8% omission. - The 2 rats running on the baseline trials are performing at less than criterion rates with one rat showing 60% accuracy and 37% omission rate whereas second rat performed with 40% accuracy and 25% omissions today. We also have 3 rats that will be subjected to baseline …show more content…
The 3rd rat performed with accuracy rates of 37% and omission rates of 46%. We are planning to motivate them further by restricting their diet even more (80% body weight)
- Remaining 2 rats are on the S6b schedule showing stable performance this week with an average accuracy rates of 40% accuracy and 55% omissions.
2) AEP and MMN protocols - Shank3 Rats:
- I finished editing the schedule for MMN flip-flop oddball sequence. We now have a schedule that runs a burst train of a standard tone (2.0 kHz) with a deviant tone (5.1 kHz) in between with a presentation rate of 87.5% standard tone and 12.5% deviant tone
- I have incorporated the presentation rates in the schedules such that the flipped standard tone (5.1 kHz) will also have 87.5% presentation rate once the flip occurs.
- Thus, we now have 2 AEP protocols for 2kHz and 5.1kHz tone, an MMN odd-ball sequence running a standard tone of 2kHz at 85% presentation rate with 15% deviant tone presentation, an MMN deviant-only schedule producing a 5.1kHz deviant tone with 15% presentation rate pseudorandomly and an MMN schedule with flip-flop
Below is my weekly update for this week from 24th Aug '16 to 26th Aug '16.
1) FMR1 5-choice training:
- At the end of the 9th week of the Fmr1 rat training, we have 1 rat that finished the challenge trials running on reminder S8b schedules. It is a male wild type that performed with more than 75% accuracy with fewer than 10% omissions. The second rat was run on baseline schedule today and it performed exceptionally well with 88% accuracy and 8% omission. - The 2 rats running on the baseline trials are performing at less than criterion rates with one rat showing 60% accuracy and 37% omission rate whereas second rat performed with 40% accuracy and 25% omissions today. We also have 3 rats that will be subjected to baseline …show more content…
The 3rd rat performed with accuracy rates of 37% and omission rates of 46%. We are planning to motivate them further by restricting their diet even more (80% body weight)
- Remaining 2 rats are on the S6b schedule showing stable performance this week with an average accuracy rates of 40% accuracy and 55% omissions.
2) AEP and MMN protocols - Shank3 Rats:
- I finished editing the schedule for MMN flip-flop oddball sequence. We now have a schedule that runs a burst train of a standard tone (2.0 kHz) with a deviant tone (5.1 kHz) in between with a presentation rate of 87.5% standard tone and 12.5% deviant tone
- I have incorporated the presentation rates in the schedules such that the flipped standard tone (5.1 kHz) will also have 87.5% presentation rate once the flip occurs.
- Thus, we now have 2 AEP protocols for 2kHz and 5.1kHz tone, an MMN odd-ball sequence running a standard tone of 2kHz at 85% presentation rate with 15% deviant tone presentation, an MMN deviant-only schedule producing a 5.1kHz deviant tone with 15% presentation rate pseudorandomly and an MMN schedule with flip-flop