Explain Why Curcumin Has Been Loaded Into Many Nanocarriers

Curcumin has been loaded into many nanocarriers, while it’s a meaningful attempt to load it into a typical protein capsid lumazine synthase. The highly symmetrical structure of AaLS-IC capsid can improve drug loading capacity and the biocompatibility of AaLS-IC capsid can improve the solubility of curcumin and protect it from environment. In addition, the simple and high-efficient process of curcumin loading and unnloading are also attractive. After a two-step reaction, the AaLS-IC-cur can be made and the yield of AaLS-IC-cur is 70%, it’s mainly depended on the reduction of the activated disulfide 5,5’-dithiobisnitrobenzoic acid (DTNB). It’s a high enough yield for curcumin loading.
4.2 The solubility of AaLS-IC-cur
Loading cur-SH into