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Epigenomics And Chromatin

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Epigenomics And Chromatin
Nowadays, the interactions between the epigenomics and transcriptomics are widely studied. The interplay between the chromatin and transcription factors is very complicated (Angelini & Costa 2014). Chromatin is composed of DNA that is wrapped around nucleosomes to form domains of accessible (open) and inaccessible (closed) chromatin. The histone proteins regulate the chromatin accessibility. Accessible chromatin can facilitate association of transcription factors to DNA (Angelini & Costa 2014). Some transcription factors are capable of modifying the chromatin around their binding site, which can then recruit new transcription factors and chromatin-modifying factors to the region. Such changes cause cell differentiation so the chromatin domains
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