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Epigenetic Change

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Epigenetic Change
HCC is one of the deadliest cancer worldwide and it’s the fifth cancer in the world. Several epigenetic factors underlie the progressiveness of HCC, including invasion, distant metastasis and hematological dissemination. Epigenetics are related to heritable phenotypic change that does not derive from a modification of the genome that may result from environmental factors, or be part of normal developmental program. Epigenetics alteration has been reported in HCC, include, DNA hyper\hypo-methylation, histone disruption and non-coding RNAs as manifested by altered expression of mirco-RNA [14] [15]. Those epigenetic changes can be used for diagnostic purposed, as well for prognosis. For example, liver specific DNA methylation can be guide the
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