Drug Dosage

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Name: ______________________________________ Date: ________________________

Student Exploration: Drug Dosage

Vocabulary: controlled release, dosage, drug, overdose, target organ

Prior Knowledge Question (Do this BEFORE using the Gizmo.)

Suppose you take aspirin for a headache. What happens after you swallow the pill?

The aspirin starts begins to dissolve by the enzymes and are soaked in while traveling down to the stomach. They then are distributed to the areas that need the pain relief.

Gizmo Warm-up
A drug is a substance that causes changes in how your body functions. When you swallow a pill, the pill dissolves in your digestive system and the drug is absorbed into your bloodstream. Many drugs are designed to affect specific target organs.

The Drug Dosage Gizmo™ allows you to monitor the concentration of drugs in the bloodstream and target organ of a patient. To begin, check that Pill Type A is selected. Pill A is a general painkiller similar to aspirin. Click Play ([pic]) and press the Take Pill button.

1. Click Pause ([pic]) after about 10 minutes of simulated time. In the Body Chemistry panel, observe the concentration of drug in the blood. The unit of concentration is micrograms per cubic centimeter (mcg/cc).

Has any drug entered the bloodstream after 10 minutes? No

2. Change the simulation speed to 2, and press Play. Click Pause when the BLOOD value starts to increase. How long does it take for the drug to reach the blood? It takes about 40 minutes for the aspirin to reach the blood

3. Click Play, and then click Pause when the patient starts to smile. Approximately what concentration of drug is needed to relieve the patient’s pain? It takes about 2 pills to make the patient feel no pain.

|Activity A: |Get the Gizmo ready: |[pic] |
| |Click Reset ([pic]).

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