Dichlorovos Case Study
ABSTRACT
The pesticides are one of the most potentially harmful chemicals liberated in the environment in an unplanned manner. Dichlorovos is widely used as a potent pesticide in many countries and has been shown to produce some adverse health effects. This study was designed to clarify whether dichlorovos an organophosphorus (OP) compound causes detectable adverse effects on rat testes. Dichlorovos was administered to rats orally at dose level of 20 mg/kg/body wt./day for 45 days. Sex organ weight analysis, fertility, biochemical, enzymatical and hormonal parameters were the criteria used to evaluate the toxicity of the dichlorovos in treated rats. Study shows significant decline in the weight of testes, epididymis, seminal vesicle, ventral prostate and reduction in sperm counts both in epididymis and testes in toxicated animals. Pre and post fertility test showed 80 % -ve results after treatment. A significant reduction in the testicular glycogen and sialic acid was also noticed. Contrary to these, protein and cholesterol contents of testes were significantly increased. In addition, acid phosphatase activity was significantly increased, while alkaline phosphatase, testosterone, LH and FSH levels were diminished. Thus obtained results collectively indicated that …show more content…
Decrease in testicular sialic acid concentration may be due to anti spermatogenic activity or reduced androgen production (Gupta et al., 2001) or may be due to the impairment in the functional ability of spermatozoa (Anbalagan et al., 2003). Increased level of cholesterol may be due to decreased androgen production, which resulted in accumulation of cholesterol in testes and thus impaired spermatogenesis (Ngoula et al.,
The pesticides are one of the most potentially harmful chemicals liberated in the environment in an unplanned manner. Dichlorovos is widely used as a potent pesticide in many countries and has been shown to produce some adverse health effects. This study was designed to clarify whether dichlorovos an organophosphorus (OP) compound causes detectable adverse effects on rat testes. Dichlorovos was administered to rats orally at dose level of 20 mg/kg/body wt./day for 45 days. Sex organ weight analysis, fertility, biochemical, enzymatical and hormonal parameters were the criteria used to evaluate the toxicity of the dichlorovos in treated rats. Study shows significant decline in the weight of testes, epididymis, seminal vesicle, ventral prostate and reduction in sperm counts both in epididymis and testes in toxicated animals. Pre and post fertility test showed 80 % -ve results after treatment. A significant reduction in the testicular glycogen and sialic acid was also noticed. Contrary to these, protein and cholesterol contents of testes were significantly increased. In addition, acid phosphatase activity was significantly increased, while alkaline phosphatase, testosterone, LH and FSH levels were diminished. Thus obtained results collectively indicated that …show more content…
Decrease in testicular sialic acid concentration may be due to anti spermatogenic activity or reduced androgen production (Gupta et al., 2001) or may be due to the impairment in the functional ability of spermatozoa (Anbalagan et al., 2003). Increased level of cholesterol may be due to decreased androgen production, which resulted in accumulation of cholesterol in testes and thus impaired spermatogenesis (Ngoula et al.,