Depression

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1.
Glucose metabolism in the insula and cingulate is affected by systemic inflammation in humans.
Hannestad J. Subramanyam K. Dellagioia N. Planeta-Wilson B. Weinzimmer D. Pittman B. Carson RE.
Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations and Ovid MEDLINE(R)
Journal of Nuclear Medicine. 53(4):601-7, 2012 Apr.
[Journal Article. Randomized Controlled Trial. Research Support, N.I.H., Extramural]
UI: 22414635
UNLABELLED: Depression is associated with systemic inflammation, and the systemic inflammation caused by endotoxin administration elicits mild depressive symptoms such as fatigue and reduced interest. The neural correlates of depressive symptoms that result from systemic inflammation are poorly defined. The aim of this study was to use (18)F-FDG PET to identify brain regions involved in the response to endotoxin administration in humans.
METHODS: Nine healthy subjects received double-blind endotoxin (0.8 ng/kg) and placebo on different days. (18)F-FDG PET was used to measure differences in the cerebral metabolic rate of glucose in the following regions of interest: insula, cingulate, and amygdala. Serum levels of tumor

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