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Denham Harman Free Radical Aging

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Denham Harman Free Radical Aging
In 1956, Denham Harman articulated the free radical theory of aging which states that ‘oxygen free radicals that are formed endogenously in live cells result in a pattern of cumulative damage’(9). The theory is also implied that the target of those radicals in the cellular system is random. In live cells, DNA, protein and lipid are targets for the free radical’s invasion. Damaging any of those vital macromolecules in live cell affects the physiology of the cell and may lead to apoptosis and cell death. Cell injury caused by reactive oxygen species (ROS), radicals such as hydroxyl radical (OH∙) and the nonradicals like hydrogen peroxide H2O2, appears to be a measure contributor for many aging diseases such as cancer, diabetes, cardiovascular
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