Dengue Virus Infection
I. What is the name of the disease? What is the name of the pathogen that causes this disease? A. Dengue fever
1. Four related viruses
2. DENV 1, DENV 2, DENV 3 or DENV 4
B. Dengue Virus Infection
II. What are some characteristics of the pathogen? How is the pathogen grown in the lab? A. Single stranded RNA virus
1.Positive strand virus of the family Flaviviridae
2. Virus enveloped with a lipid membrane.
B. Replication grown in serum
1. Original cell isolated from larvae or human sera.
2. Incubation very depending of phase of virus.
3. Acute-phase and convalescent phase serum samples.
III. What is the epidemiology for this disease? Who gets the disease? How common is it? A. Mosquito borne viral disease
1. Originated in monkeys then being spread to humans.
2. Etiology of dengue was established by 1940s.
3. Dengue shock syndrome and Dengue hemorraghic fever (separate disease). B. Western Hemisphere, outbreak in Hawaii.
1. People who live and travel in tropics and subtopics.
2. Endemic in Puerto Rico, Latin America, Southeast Asia, Samoa and Guam.
3. 100 million people are infected yearly.
IX. Describe the disease, how is the disease spread? How does the pathogen get into the body? What does it do inside the body? A. Dengue fever is a virus caused disease that is spread by mosquitoes.
1. Aedes aegypit mosquito in western hemisphere.
2. Aedes albopictus mosquito in Hawaii.
3. infected by mosquito, virus is present in blood, neutralizing antibodies and activation of T lymphocytes. Fatigue, headache, joint aches, muscle aches, nausea, fever, swollen lymph nodes, vomiting. X. How is the disease diagnosed and any test might be done? Treatment or supportive measures? A. Must be diagnosed in hospital.
1. Complete blood count.
2. Polymerase chain reaction.
3. Antibody titer.
B. No treatment
1. Take analgesics- avoid aspirin
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