Clostridium Perfringens Case Study

Good Essays
Key words: Clostridium perfringens, diarrhea, dog, hemorrhagic gastroenteritis.

Introduction Enteric clostridial infection in dogs are life-threatening condition usually caused by Clostridium perfringens and Clostridium difficile. The pathogenesis of enteric clostridial infection requires two factors; the presence of these microorganisms in the intestine and a change in the enteric microenvironment. C. perfringens is a Gram-positive, spore-forming, obligately anaerobic, non-motile bacillus and capable of toxin production.
Materials and methods
Case history: A male Maltese dog, weighing 2.04 kg, was died on the way to the animal hospital with clinical signs of weakness, large volume of bloody diarrhea but no vomit. The previous day the
…show more content…
Many necrotic enterocytes, characterized by karyorrhexis and karyolysis, were seen and there were moderate numbers of lymphocytes and plasma cells infiltrated at the lamina propria and some areas of the intestinal submucosal layer. The serosal neurons were dark and swollen. The spleen showed a focal fibrosiderotic plaque and occasionally fibrin thrombi in the blood vessels. The kidney revealed mild multifocal necrosis of the tubular epithelial cells with diffuse congestion and multifocal cysts at the cortex. The liver sinusoids were markedly expanded by blood. The alveolar capillaries were markedly expanded by red blood cells and increased number of neutrophils and some fibrin thrombi were seen. Figure…

Clinical pathology: There were all negative on antigen rapid canine parvovirus/canine coronavirus (CPV/CCV) antigen test kit. The sample from small intestine was submitted for bacterial culture.
Bacterial cultures: a bacterial culture from intestinal sample isolated large numbers of C. perfringens on ….. agar plates incubated at 37◦C overnight in anaerobic conditions.

Figure… Colonies on blood agar, which are surrounded by a double zone of

You May Also Find These Documents Helpful

  • Good Essays

    Clostridium Perfringens

    • 609 Words
    • 3 Pages

    Clostridium Perfringens Clostridium perfringens (formerly known as C. welchii, or Bacillus welchii) is a Gram-positive, rod- shaped, anaerobic, spore-forming bacterium of the genus Clostridium. C. perfringens is ever present in nature and can be found as a normal component of decaying vegetation, marine sediment, the intestinal tract of humans and other vertebrates, insects, and soil. Infections due to C. perfringens show evidence of tissue necrosis, bacteremia, emphysematous cholecystitis…

    • 609 Words
    • 3 Pages
    Good Essays
  • Best Essays

    Clostridium Perfringens

    • 2733 Words
    • 11 Pages

    Holly Serna Sharon Eden BIO 186-01 October 27, 2011 Clostridium perfringens Clostridium perfringens is not the 24 hour flu although it is often confused with being. It is one of the most wide spread foodborne pathogens in the world, commonly referred to as the "food service bug" 1. The type A strain of C. perfringens is caused by a bacterial infection that releases alpha-toxins and is associated with undercooked and improperly handled meats. This type of food poisoning, although usually…

    • 2733 Words
    • 11 Pages
    Best Essays
  • Better Essays

    Clostridium Perfringens

    • 815 Words
    • 4 Pages

    Foodborne Illness Week 4 Laura Shepherd SCI/163 November 26, 2012 Raymond Kahler Foodborne Illness Week 4 Clostridium perfringens One of the most common foodborne illnesses in the United States is Clostridium perfringens (C.perfringens). According to the Center for Disease Control, it is responsible for approximately one million cases of foodborne illness each year (Center for Disease Control, 2011). This bacterium is an anaerobic gram-positive bacterium. This means that it requires little…

    • 815 Words
    • 4 Pages
    Better Essays
  • Good Essays

    Clostridium difficile also called C. difficile, it is an inflammation of the colon caused by the bacteria that can caused swelling and irritation of the large intestine, or colon. clostridium difficile is a bacterium that causes diarrhea and more serious intestinal condition such as colitis. Clostridium difficile is recognized as a toxin producing anaerobic bacterium responsible for colitis infection. The main risk factors for clostridium difficile infections are antibiotic exposure, hospitalization…

    • 651 Words
    • 3 Pages
    Good Essays
  • Good Essays

    Clostridium difficile as a gram positive, spore like bacteria mainly in hospital and widely spread in the community. It causes infection in human intestines such as diarrhea and pseudomembranous colitis. Clostridium difficile original is necessary in human body which helps maintain gastrointestinal balance and body normal regulation. However, overproduction of Clostridium difficile causes Clostridium difficile infections (CDI), overgrowth of bacteria become spore form leading to release two exotoxins…

    • 608 Words
    • 3 Pages
    Good Essays
  • Good Essays

    Clostridium difficile infection (CDI) can develop in any patients, challenging healthcare professionals to provide early and thorough assessment of those at risk. Nursing consideration for patients with CDI should be hand hygiene, contact isolation and meticulous environmental cleaning. In conclusion, health care professionals should remember CDI has serious and detrimental effect on patient’s well being and can lead to fatal outcome.…

    • 61 Words
    • 1 Page
    Good Essays
  • Good Essays

    Clinical Features The incubation period for Clostridium tetani Infection is from three to twenty - one days. In most cases tetanus is found within 10 days of contact with the bacteria. The incubation period is depending on the severity of the infection. When the wound is deep or more infected with the C. tetani the incubation period will be shorter and the chances of death are high. When contacted with C. tetani some of the symptoms can include involuntary muscle tightening such as stiffness in…

    • 532 Words
    • 3 Pages
    Good Essays
  • Good Essays

    Clostridium Perfingens

    • 686 Words
    • 3 Pages

    Clostridium Perfringens is a spore forming gram-positive bacterium. C. Perfringens is found in the intestines of animals and humans as well as many environmental sources. It can survive in little or no oxygen and is found on raw meat and poultry. According to the Center for Disease Control (2011), C. Perfringens is one of the most common causes of foodborne illness in the United States and causes nearly one million cases of foodborne illness each year (Center for Disease Control, 2011). People get…

    • 686 Words
    • 3 Pages
    Good Essays
  • Good Essays

    Clostridium Difficile

    • 692 Words
    • 3 Pages

    Clostridium Difficile | | Clostridium Difficile is a Gram-positive, toxin-producing anaerobic bacterium belonging to the family Clostridiaceae of the Clostridiales. Though strictly oxygen-intolerant, C. Difficile is able to produce aero tolerant endospores under unfavorable conditions that are capable of persisting in an open environment for years. C. Difficile is a commensalist species typically housed in the colonic fecal flora of a fairly small subset of the child population, with the number…

    • 692 Words
    • 3 Pages
    Good Essays
  • Better Essays

    Clostridium Difficile

    • 1213 Words
    • 5 Pages

    Diagnosis of Clostridium Difficile INTRODUCTION Clostridium Difficile Infection is currently the most commonly found cause of diarrhoea in relation to antibiotic treatments in hospitals. Although C.difficile infections are common, there are only a limited methods of diagnosing accurately if a patient has been affected. I will be discussing methods of diagnosis, pros and cons and statistical facts regarding C.difficile infection. METHODS OF LABORATORY DIAGNOSIS There are several methods…

    • 1213 Words
    • 5 Pages
    Better Essays