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Organic Chemistry I CHM 3201 4 (3+1) 160 hours per semester
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None At the end of the course, students will be able to: 1. Define and explain the basic concepts in organic chemistry such as electronegativity, orbital hybridization, nomenclature, resonance and isomerism, as well as organic reactions mechanisms (C4, CTPS) 2. to conduct experiments that demonstrate the characteristic reactions of important functional groups of organic compounds (P4) 3. interact and work together as a group, as well as carry out a given assignment within the stipulated time (A3)
SYNOPSIS
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This course covers topics related to structure, bonding, nomenclature, properties, reactions, synthesis and the importance of the various classes of organic compounds, as well as optical isomerism.
CONTENTS LECTURES : 1. Introduction
CONTACT HOURS 4 Electronegativity. Ionic, covalent and polar covalent bonds. Bond breaking. Nucleophiles, electrophiles and free radicals. Lewis acid and Lewis base. Orbital hybridization: sp3, sp2, sp. Conjugated double bonds and resonance 2. Classification of organic compounds Nomenclature: homologues series, alkanes, cycloalkanes, alkene, alkynes, alkyl halides, alcohols, amines, aldehydes, ketones and carboxylic 4
acids and their derivatives. 3. Stereochemistry Conformations of alkanes and cycloalkanes. Isomerism and optical activity. Structural isomers and stereoisomers. Geometrical isomers: (E) and (Z) systems. Enantiomers and diastereoisomers; chirality, plane polarized light, racemization and absolute configuration. 4. Single bonded functional groups 4 Alkyl halides: Classification and characteristics. Reactions, SN1, SN2, E1, E2 and their mechanisms, Grignard reagents Alcohols and ether: Synthesis, dehydration and oxidation of alcohols. Ether cleavage. Amines: Nucleophilic substitution, basicity and reaction with nitrous acid. 5.
References: : 1. Fessenden, R. J. & Fessenden, J. S. (1998). Organic Chemistry 6th edition.California: Brooks/Cole. 2. Loudon, G. M. (2002). Organic Chemistry. 4th edition. New York: Oxford Univesity Press. 3. Mc Murry, J. E. (2003). Organic Chemistry. 5th edition, Pacific California: Brooks/Cole. 4. Solomons, T. W. G. & Fryhle, C. B. (2003). Organic Chemistry. 8th edition. New York: John Wiley and Sons.