Central Giant Cell Galuloma Case Study Answers
CENTRAL GIANT CELL GRANULOMA – A CASE REPORT AND REVIEW OF LITERATURE
ABSTRACT
INTRODUCTION
Central Giant Cell Granuloma also termed as Reparative Giant Cell Granuloma is an uncommon benign intraosseous lesion. It was first introduced by Jaffe in 1953 to distinguish it from Giant Cell Tumor of bone. World Health Organization has defined it as an intraosseous lesion consisting of cellular fibrous tissue with multiple hemmorhagic foci, aggregations of multinucleated giant cells and occasionally trabeculae of woven bone.
CGCG accounts for less than 7% of all benign lesions of the jaws. Clinically, it occurs most commonly in patients younger than 30 years old with a female predilection. Most commonly, lesions are located in anterior mandible …show more content…
Initially the swelling was small and gradually it increased to the present size. Pain in the involved region was mild, spontaneous, intermittent and is relieved on taking medications. Past dental history was extraction of tooth from the same region 15 days back as the tooth was grossly decayed with no pain and extraction of left mandibular first molar 1 yr back. There was no relevant medical history of any systemic disease or any drug allergy. On extraoral examination, there was facial asymmetry with a diffuse swelling on right side of lower jaw extending upto the canine region. The overlying skin appeared to be normal. The swelling was bony hard in consistency and non tender on palpation. On intraoral examination, swelling was present on buccal aspect of approximately 1.5cmx1cm extending from distal aspect of second premolar till the mesial aspect of second molar with normal appearing overlying mucosa. The margins were well defined with smooth surface. The swelling was bony hard to palpation and there was missing permanent first molar with obliteration of buccal sulcus in the involved …show more content…
On histological examination, CGCG exhibits highly vascular and cellular granulation tissue with multinucleated giant cells scattered in the connective tissue stroma. Extravasated RBCs with hemosiderin and bone formation may be seen occasionally. In the present case, plump fibroblasts were seen in connective tissue stroma with multinucleated giant cells of varying size and containing nuclei upto 20 in number. Scattered hemosiderin pigments and extravasated RBCs were also
ABSTRACT
INTRODUCTION
Central Giant Cell Granuloma also termed as Reparative Giant Cell Granuloma is an uncommon benign intraosseous lesion. It was first introduced by Jaffe in 1953 to distinguish it from Giant Cell Tumor of bone. World Health Organization has defined it as an intraosseous lesion consisting of cellular fibrous tissue with multiple hemmorhagic foci, aggregations of multinucleated giant cells and occasionally trabeculae of woven bone.
CGCG accounts for less than 7% of all benign lesions of the jaws. Clinically, it occurs most commonly in patients younger than 30 years old with a female predilection. Most commonly, lesions are located in anterior mandible …show more content…
Initially the swelling was small and gradually it increased to the present size. Pain in the involved region was mild, spontaneous, intermittent and is relieved on taking medications. Past dental history was extraction of tooth from the same region 15 days back as the tooth was grossly decayed with no pain and extraction of left mandibular first molar 1 yr back. There was no relevant medical history of any systemic disease or any drug allergy. On extraoral examination, there was facial asymmetry with a diffuse swelling on right side of lower jaw extending upto the canine region. The overlying skin appeared to be normal. The swelling was bony hard in consistency and non tender on palpation. On intraoral examination, swelling was present on buccal aspect of approximately 1.5cmx1cm extending from distal aspect of second premolar till the mesial aspect of second molar with normal appearing overlying mucosa. The margins were well defined with smooth surface. The swelling was bony hard to palpation and there was missing permanent first molar with obliteration of buccal sulcus in the involved …show more content…
On histological examination, CGCG exhibits highly vascular and cellular granulation tissue with multinucleated giant cells scattered in the connective tissue stroma. Extravasated RBCs with hemosiderin and bone formation may be seen occasionally. In the present case, plump fibroblasts were seen in connective tissue stroma with multinucleated giant cells of varying size and containing nuclei upto 20 in number. Scattered hemosiderin pigments and extravasated RBCs were also