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Brown Recluse Spider Research Paper

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Brown Recluse Spider Research Paper
Shane Miller

Brown Recluse

The brown recluse spider lives inside houses as well as in its surroundings. Inside homes, the arachnid lives in dark places, such as cracks, corners, seldom used clothes, curtains and inside furniture. Yet, it is very common for a spider to get trapped in showers and bathtubs because of their smooth surface, and there have been lots of cases in which spiders bit the legs of a person who was having a bath. Outdoors, the BRS is usually located underneath rocks or within hollow woods. If you live in areas where the BRS lives, you must be careful when manipulating garden objects such as boxes, piles of wood, pots, etc.

In the United States, reports of severe envenomations by brown spiders began to appear in
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Loxoscelism is the term used to describe the systemic clinical syndrome caused by envenomation from the brown spiders.

Brown recluse spider bites can cause significant cutaneous injury with tissue loss and necrosis. Less frequently, more severe reactions develop, including systemic hemolysis, coagulopathy, renal failure, and, rarely, death.

Brown recluse venom, like many of the other brown spider venoms, is cytotoxic and hemolytic. It contains at least 8 components, including enzymes such as hyaluronidase, deoxyribonuclease, ribonuclease, alkaline phosphatase, and lipase. Sphingomyelinase D is thought to be the protein component responsible for most of the tissue destruction and hemolysis caused by brown recluse spider envenomation. The intense inflammatory response mediated by arachidonic acid, prostaglandins, and chemotactic infiltration of neutrophils is amplified further by an intrinsic vascular cascade involving the mediator C-reactive protein and complement activation. These and other factors contribute to the local and systemic reactions of necrotic
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Recently, reports of persons with "spider bites" presenting to emergency departments have reached near urban legend proportions, prompting many physicians to question the diagnosis of a brown recluse bite in nonendemic areas. The list of conditions that can present in a similar fashion to that of a brown recluse spider envenomation is extensive. A more likely explanation for this epidemic of spider bites is in fact community-acquired methicillin-resistant Staphylococcus aureus (MRSA) skin

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