Bone Remodeling: Regulating Bone Strength and Mineral Homeostasis

Pages: 2 (601 words) Published: August 7, 2013
Bone remodeling is the process by which bone is restored to regulate bone strength and mineral homeostasis. Remodeling of the bone entails that a continuing removal of discrete packets of old bone, the replacement of these packets with newly synthesized proteinaceous matrix, and subsequent mineralization of the matrix to form new bone. The remodeling unit is made up of tightly grouped osteoclasts and osteoblasts that discharge the resorption of old bone and formation of new bone. The order of the bone remodeling process is activation, resorption, reversal, and formation. The activation step relays on cells of the osteoblast lineage, either on the surface of the bone or in the marrow, acting on blood cell precursors (hematopoietic cells) to form bone-resorption osteoblast. The resorption process can take place under the lining cells. After the reversal phase, the osteoblasts start to create new bone. A few of the osteoblasts stay inside the bone and are altered to osteocytes, which are attached to another and to the surface osteoblast. The resorption process last only a couple of weeks but the formation phase takes much longer, multiple layers of new bone are formed by successive waves. The description of a condyle is a round bump or large rounded prominence. The type of body marking of the condyle is a smooth, rounded articular surface. An example of condyle is the medial condyle of the femur bone. The description of a crest is a moderately raised and consequently prominent border or ridge. The type of body marking of the crest is a narrow ridge of bone. An example of the crest is the ilium (bone). The description of the epicondyle is that is has a bump close to the condyle. It also has the appearance of “bump on a bump”; for muscle attachment. The type of body marking of the epicondyle is a bony bulge adjacent or above condyle. An example of the epicondyle is the medial epicondyle of the humerus, which is bigger and more prominent than the lateral epicondyle....
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