Bone Remodeling

Bone tissue continuously renews itself throughout life as a result of a variety of stimuli by the process of bone remodeling, in which old bone is replaced by new bone in order to preserve bone strength and mineral stability. It requires a particular balance between bone deposition and resorption, by the combined action of osteoblasts and osteoclasts, respectively. This process prevents the accumulation of bone micro-damage, removing injured bone and reshaping bones in response to use and disuse (Clarke, 2008; Little et al., 2011; Saladin et al., 2018). Occasionally, an unbalance among the activity of bone cells leads to a series of skeletal disorders, such as osteoporosis. Osteoporosis is a common metabolic disorder of the skeleton that occurs