Bone marrow transplantation
Bone marrow transplantation
Bone marrow transplantation is a process used to transfer a soft inner part of bone tissue from donor to recipient. It used for patient with certain leukemia or hematopoietic disease. Bone marrow transplantations prescribed to substitute a mal functioning patients bone marrow with a healthy donated marrow that histologically compatible to patient body to insure the maximum beneficence. Bone marrow aspired from donor then treated and frozen till the recipient is ready. The success of this procedure measured by ability the of transplanted marrow to engraft and become capable of producing healthy blood cells. 1,
Other possibility for stem cell transplantation, could be peripheral blood (allogeneic transplants), or cord blood. Patient's own stem cells can be used in what are called autologous transplant. In comparison between allogeneic peripheral blood stem cell transplantation (PBSCT) to bone marrow transplantation (BMT), PBSCT shows faster engraftment, more GVHD, a decrease in relapse and improved disease-free survival, a similar mortality and overall survival when compared with BMT in HLA- test identical sibling transplantation for hematologic malignancies.2
Further study evaluating peripheral stem to bone marrow stem by Anasetti; conducted on 551 patients to investigate the survival probabilities between two groups of patient; one has bone marrow transplantation and another group has peripheral blood stem cell transplantation with unrelated donors. By the use of an intention-to-treat analysis Anasetti had extracted that survival rate among bone marrow transplant group was 46% while it was 51% among the peripheral-blood group. This finding illustrates that there is no significant survival differences between bone marrow transplantation and peripheral-blood stem-cell from non-relatives donors.3.
However, peripheral blood stem cell is new hope for treating patient with Sickle cell disease (SCD). Sickle cell anemia is a
Bone marrow transplantation is a process used to transfer a soft inner part of bone tissue from donor to recipient. It used for patient with certain leukemia or hematopoietic disease. Bone marrow transplantations prescribed to substitute a mal functioning patients bone marrow with a healthy donated marrow that histologically compatible to patient body to insure the maximum beneficence. Bone marrow aspired from donor then treated and frozen till the recipient is ready. The success of this procedure measured by ability the of transplanted marrow to engraft and become capable of producing healthy blood cells. 1,
Other possibility for stem cell transplantation, could be peripheral blood (allogeneic transplants), or cord blood. Patient's own stem cells can be used in what are called autologous transplant. In comparison between allogeneic peripheral blood stem cell transplantation (PBSCT) to bone marrow transplantation (BMT), PBSCT shows faster engraftment, more GVHD, a decrease in relapse and improved disease-free survival, a similar mortality and overall survival when compared with BMT in HLA- test identical sibling transplantation for hematologic malignancies.2
Further study evaluating peripheral stem to bone marrow stem by Anasetti; conducted on 551 patients to investigate the survival probabilities between two groups of patient; one has bone marrow transplantation and another group has peripheral blood stem cell transplantation with unrelated donors. By the use of an intention-to-treat analysis Anasetti had extracted that survival rate among bone marrow transplant group was 46% while it was 51% among the peripheral-blood group. This finding illustrates that there is no significant survival differences between bone marrow transplantation and peripheral-blood stem-cell from non-relatives donors.3.
However, peripheral blood stem cell is new hope for treating patient with Sickle cell disease (SCD). Sickle cell anemia is a