Diño, Claire G.
June 22, 2015
1. Which is more closely related to drug response, the total drug dose administered or the concentration of the drug in the body? The concentration of the drug in the body is more closely related to drug response because as the concentration increases, the response rises to maximum. But as you increase the concentration above 80%, maximal response achieves very little in terms of extra therapeutic effects, but increases the risk of adverse effects.
2. Why do individualized dosing regimens need to be determined for some patients?
Individualized dosing regimens need to be determined for some patients because everyone has their own characteristics and comorbidities. Some patients respond to lower drug doses while others need high drug doses to achieve therapeutic outcome.
3. Why are drug concentrations more often measured in plasma rather than whole blood or serum? Drug concentration are more often measured in plasma rather than whole blood or serum because Whole blood samples are generally harder to process and assay than serum or plasma samples. Plasma may be considered a liquid tissue compartment in which the drug in the plasma fluid equilibrates with drug in the tissues and cellular components.
4. What are the differences between bound drug, unbound drug, total drug, parent drug, and metabolite drug concentrations in the plasma? Bound drug is the amount of drug that is bounded in the plasma protein and keeps it in the blood stream. Unbound drug are the ones filtered from the plasma before drug concentration are measured. Total drug is the drug concentration measured in unfiltered plasma. Parent Drug is the first drug to be discovered and has a whole concentration while Metabolite Drug is an active form of drug after it has been processed by the body.
5. Where do we obtain data regarding drug concentrations?
Drug concentration can be obtained by blood serum or plasma in the most direct...
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