Topics: Cancer, Cell cycle, Chromosome Pages: 4 (1023 words) Published: December 16, 2010
1. Read the press release on the 2001 Nobel Prize. Summarize in a few paragraphs the accomplishments of these scientists, and the relevance of their discoveries. (Answer in 500 words or less. Send to instructor)

The Nobel Prize in Physiology or Medicine 2001 was awarded jointly to Leland H. Hartwell, Tim Hunt and Sir Paul M. Nurse "for their discoveries of key regulators of the cell cycle". They have identified key molecules that regulate the cell cycle in all eukaryotic organisms, including yeasts, plants, animals and human. These fundamental discoveries have a great impact on all aspects of cell growth. Defects in cell cycle control may lead to the type of chromosome alterations seen in cancer cells. This may in the long-term open new possibilities for cancer treatment.

2. Read the FAQ about skin cancer from The Skin Cancer Foundation and the Center for Disease Control and Prevention. Also read about the leading type of skin cancer, basal cell carcinoma, squamous cell carcinoma and melanoma.

a) Is skin cancer a concern for you? Why or why not? (Answer in 200 words or less. Send to bulletin board)

Yes, Everyone has some risk of skin cancer. Most skin cancers are associated with ultraviolet radiation from the sun or tanning beds, and many people of color are less susceptible to UV damage thanks to the greater amounts of melanin (the protective pigment that gives skin and eyes their color) darker skin produces. But people of color can still develop skin cancer from UV damage. Additionally, certain skin cancers are caused by factors other than UV such as genetics or other environmental influences and may occur on parts of the body rarely exposed to the sun.

b) Based on what you have learned in this lesson, which cells of skin are likely to be the source of cancerous cells? What do you think would happen to the differentiation process in cancerous skin cells? (Answer in 200 words or less. Send to instructor)

Differentiation therapy is based on the...
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