Bellamya Bengalensis Case Study

Bellamya bengalensis (common name:burang) is distributed widely in southern Asia and India. The materia medica of India provides a great deal of information of the folklore practices and traditional aspects of therapeutically important natural products [21]. For instance, traditional Indian medicine, especially Siddha and Ayush medical preparations, the opercula of grastropods are used as an ingredient of combat different diseases [22]. Likewise, the traditional system of medicine the shells of mollasc Cypraea moneta, have been used as medicine to cure various ailments mainly related with stomach and in the treatment of dyspepsia, jaundice, enlarged spleen, liver, asthma, cough are also reported to be externally used as caustic in various forms of ointments [23]. The present study reveals anti-inflammatory, analgesic activity of extrapallial fluid of Bellamya Bengalensis, a fresh water mollusc.
Acute toxicity revealed that the fluid is safe upto 2000 ml/100g of body weight dose orally.
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PG3 elicits pain by direct stimulation of sensory nerve endings and also sensitizes sensory nerve endings to other pain provoking stimuli. Since the extrapallial fluid of Bellamya bengalensis has shown significant analgesic and anti-inflammatory activities, the probable mechanism could be by the inhibition of the PG3 synthesis. The anti-inflammatory activity may be due to either inhibition of PG biosynthesis or its anti-prostaglandin effect. Hence, there is a need for further investigation on this