Basicity Of Nucleophile

Amines are essential for the building blocks of life; they are a key component in the formation of amino acids, proteins, and nucleic acids. Amines contain nitrogen that has one lone pair; this enables it to form 3 covalent bonds with other atoms, all while staying neutral. Due to an amines basicity, reaction with an acid is very easy and forms a positively charged ammonium ion. As well as being a strong base, amines are also quite good nucleophiles. When the nitrogen is directly attached to one or two R groups is more nucleophillic than when directly attached to a hydrogen atom. The reason behind this is due to the electron donating ability of the alkyl group. However, the increasing strength of the nucleophile proves difficulty when added