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Autoimmune Disorders

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Autoimmune Disorders
Autoimmune Disorders
Dr. Frances Angelique A. Tequillo
Cebu Doctors’ University
Definitions:
* group of >80 serious, chronic illnesses

* underlying problem is the samefor all

* immune system is misdirected

* body attacking its own self

* 4th largest cause of disability (Europe & the US)

*
Demonstration of: * immunoglobulins * autoantibodies * cytotoxic T * cells * self antigens * auto-antigens
1.persistent activation of immunologic effector mechanisms
2.that change the function and integrity of cells and organs
3.sites of organ / tissue damage depend on the location of the immune reaction

Examples: ClinicalDiagnosis | Autoantigen | Addison’s Disease | p-450 | Crohn’s Disease | p-ANCA, pancreatic acinar cells | Ovarian Failure / Infertility | p-450 | Pernicious Anemia | Parietal cells | Ulcerative Colitis | p-ANCA |

Active chronic hepatitis
Addison’s disease
Autoimmune atrophic gastritis
AIHA
Dermatomyositis
Discoid lupus erythematosus
Goodpasture’s syndrome
Hashimoto’s thyroiditis
ITP
IDDM
MS
Myasthenia gravis
Pemphigus vulgaris
Pernicious anemia
Primary biliary cirrhosis
Primary myxedema
RA
Scleroderma
SLE
Thyrotoxicosis
Classification
Organ-specific * both lesions & autoAb’s confined to 1 organ
Midspectrum
* localized lesions in an organ
Organ non-specific * autoAb’s organ non-specific both lesions & autoAb’s NOT confined to 1 organ

Organ-specific disorders
• Thyroid
• Hashimoto’s thyroiditis
• Primary myxedema
• Thyrotoxicosis
• Stomach
• Pernicious anemia
• Adrenal
• Addison’s disease
• Pancreas
• Juvenile diabetes

Organ-nonspecific disorders
• Muscle
• Dermatomyositis
• Kidney
• SLE
• Skin
• Scleroderma
• Joints
• Rheumatoid arthritis

Specific vs. Non-Specific (Similarities)
1. Circulating autoantibodies react with normal body constituents.
2. Increased Ig concentration in serum often found.
3.
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