Autoimmune Dermatitis Essay
Abstract
Autoimmune progesterone dermatitis (APD) is a rare disorder characterized by recurrent skin manifestations starting during the luteal phase of a woman's menstrual cycle. Signs and symptoms of APD can present as urticaria, angioedema, erythema multiforme, and eczematous lesions, thought to be an unusual allergy to progesterone.
We describe a 46-year-old woman with an erythematous round plaque on lower lip and both arms Her skin eruptions waxed and waned for 10 mounths and were associated with her menstrual cycle. We performed an intradermal test using progesterone, which was positive. After the beginning of oral prednisolone (30 mg daily) therapy during menstruation, although slight recurrence appeared,the severity was significantly …show more content…
The eruption always recurred 3-4 days before her menstrual and persist up to 1–2 days after the end of the men¬strual cycle, leaving postinflammatory hyperpigmentations .
At her first visit, the lesions appeared as a sharply demarcated round patches with dusky brown colours.
(fig 1)
Biopsy was taken from the newest lesion.a histological study revealed…….
Based on the history and the clinical features, AIPD was suspected and progesterone challenge test with intradermaly injection of 0.1 cc progesterone on normal skin of left arm done for her.and also Saline was used as negative control on right arm.the patient visited after 24 hrs.in site of progesterone injection erythema with induration developed. These results confirmed the diagnosis of autoimmune progesterone dermatitis. The patient treated with oral prednisolone (30 mg daily) since 3 days befor mensturation till first 5 days of menstrual cycle. The eruption recurred, but with significantly reduced
Autoimmune progesterone dermatitis (APD) is a rare disorder characterized by recurrent skin manifestations starting during the luteal phase of a woman's menstrual cycle. Signs and symptoms of APD can present as urticaria, angioedema, erythema multiforme, and eczematous lesions, thought to be an unusual allergy to progesterone.
We describe a 46-year-old woman with an erythematous round plaque on lower lip and both arms Her skin eruptions waxed and waned for 10 mounths and were associated with her menstrual cycle. We performed an intradermal test using progesterone, which was positive. After the beginning of oral prednisolone (30 mg daily) therapy during menstruation, although slight recurrence appeared,the severity was significantly …show more content…
The eruption always recurred 3-4 days before her menstrual and persist up to 1–2 days after the end of the men¬strual cycle, leaving postinflammatory hyperpigmentations .
At her first visit, the lesions appeared as a sharply demarcated round patches with dusky brown colours.
(fig 1)
Biopsy was taken from the newest lesion.a histological study revealed…….
Based on the history and the clinical features, AIPD was suspected and progesterone challenge test with intradermaly injection of 0.1 cc progesterone on normal skin of left arm done for her.and also Saline was used as negative control on right arm.the patient visited after 24 hrs.in site of progesterone injection erythema with induration developed. These results confirmed the diagnosis of autoimmune progesterone dermatitis. The patient treated with oral prednisolone (30 mg daily) since 3 days befor mensturation till first 5 days of menstrual cycle. The eruption recurred, but with significantly reduced