Correlation between Autism and Control groups
Autism also known as Autism spectrum disorder (ASD) is a group of disorders of brain development. These disorders are described such as difficulties in social interaction, verbal and nonverbal communication and repetitive behaviors. People with Autism can have problems with intellectual disability, difficulties in motor coordination and attention and physical health issues such as sleep and gastrointestinal disturbances.
Mitogen inducible gene (MIG6) is an early response gene shown in many different types of tissues. It is influenced by a broad spectrum of growth factors, hormones, or stress stimuli. Some studies have shown that MG16 is requires for lung development and skin formation. It is also associated with chronic conditions.
Hepatocyte growth factor (HGF) regulates cell growth, cell motility and formation by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. It is secreted by mesenchymal cells and acts a multi-functional cytokine on cells of mainly skin origin. It has a central role in tissue regeneration, tumorogenesis and angiogenesis. The protein belongs to the plasminogen subfamily of S1 peptidases, nut has no detectable protease activity. Splicing of this gene would produce multiple transcript variants encoding different isoforms.
Epidermal growth factor (EGF) is a mitogenic protein that speeds up the healing process by causing epidermal and skin cells to divide and grow. EGF is the most potent mitosis inducing agent in the skin. Skin is always producing and using EGF, even more when skin is damaged.
Epidermal growth factor receptor (EGFR) also known as HER1 or ErbB1 is a protein found on the surface of cells that is found in high levels of cancer cells. EGFR binds to this receptor protein to allow cells to grow and divide. It plays an important role in the regulation of survival, the spread of
References: 1. Zhang, Yu-Wen, Kyle A. Furge, Ben Staal, Karl J. Dykema, and George F. Vande Woude. "PLOS ONE: Cancer-Type Regulation of MIG-6 Expression by Inhibitors of Methylation and Histone Deacetylation." PLOS ONE: accelerating the publication of peer-reviewed science. N.p., n.d. Web. 6 Oct. 2013. . 2. "Epidermal Growth Factor." CABM Structural Bioinformatics Laboratory. N.p., n.d. Web. 8 Oct. 2013.