Aspirin Synthesising And Purification All Coursework 1 1 
Abstract
In this piece of coursework I have been investigating the synthesis of Aspirin and checking for presence and purity of Aspirin.
Throughout this coursework we have looked at the history of Aspirin; industrial manufacturing; making salicylic acid; the preparation of Aspirin; recrystallization and purity; melting point; thin layer chromatography (TLC) and titration of Aspirin.
I’ve learned a lot about Aspirin, how it works and how it is made. We found out that the Aspirin we made and used was actually very pure when we tested it out against the shop brought Aspirin; we found this out by doing the TLC and titration of Aspirin.
In the Synthesis portion of the experiment I found out that we have to use oil of wintergreen instead of Phenol as it is harmful and a lot more expensive as it is used in industry, the oil of wintergreen is a safer option to use in school and it is also part reacted meaning it already has esters attached so therefor was less risk for use to use it compared to Phenol.
There were a lot of risks when performing these tests and so we had to take great precaution and stick by our risk assessments. Also a few things went wrong as well. After we carried out the preparation of Aspirin and before we recrystallized it, we came out with hardly any Aspirin 0.01g to be exact, so for the rest of the tests we had to work with other groups so that we could finish off the experiments. Other than some slight mishaps the whole of the experiment including the calculations everything when pretty smooth.
Aspirin Synthesising and Purification
History of Aspirin
The compound, from which the active ingredient in Aspirin was first found in salicylic acid, was found in the bark of a willow tree in 1763 by Reverend Edmund Stone. The bark from the willow tree contains high levels of Salicin. Earlier accounts indicate that Hippocrates of ancient Greece used willow leaves for the same purpose, to reduce fever and relieve the aches of a variety of
In this piece of coursework I have been investigating the synthesis of Aspirin and checking for presence and purity of Aspirin.
Throughout this coursework we have looked at the history of Aspirin; industrial manufacturing; making salicylic acid; the preparation of Aspirin; recrystallization and purity; melting point; thin layer chromatography (TLC) and titration of Aspirin.
I’ve learned a lot about Aspirin, how it works and how it is made. We found out that the Aspirin we made and used was actually very pure when we tested it out against the shop brought Aspirin; we found this out by doing the TLC and titration of Aspirin.
In the Synthesis portion of the experiment I found out that we have to use oil of wintergreen instead of Phenol as it is harmful and a lot more expensive as it is used in industry, the oil of wintergreen is a safer option to use in school and it is also part reacted meaning it already has esters attached so therefor was less risk for use to use it compared to Phenol.
There were a lot of risks when performing these tests and so we had to take great precaution and stick by our risk assessments. Also a few things went wrong as well. After we carried out the preparation of Aspirin and before we recrystallized it, we came out with hardly any Aspirin 0.01g to be exact, so for the rest of the tests we had to work with other groups so that we could finish off the experiments. Other than some slight mishaps the whole of the experiment including the calculations everything when pretty smooth.
Aspirin Synthesising and Purification
History of Aspirin
The compound, from which the active ingredient in Aspirin was first found in salicylic acid, was found in the bark of a willow tree in 1763 by Reverend Edmund Stone. The bark from the willow tree contains high levels of Salicin. Earlier accounts indicate that Hippocrates of ancient Greece used willow leaves for the same purpose, to reduce fever and relieve the aches of a variety of