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Aspirin Lab Report

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Aspirin Lab Report
Aspirin were used to relieve pain, inflammation, and fever. Aspirin were made using a combination of salicylic acid and acetic anhydride.The goal of this experiment was to determined the purity of aspirin using different methods. These methods included, reacting salicylic acid with FeCl3, finding its melting points, and by doing Thin-layer chromatography. When you reacted salicylic acid with FeCl3, changes in color will occur. Pure Aspirin has a melting point around 135°C and a pure salicylic acid has 158 °C. TLC is used to separate compounds based on affinity for stationary phase or mobile phase. In TLC, the solvent went up at different rates. The retention factor (Rf) of a component can then be measured by dividing the distance that was traveled by the solvent front distance.By doing this experiment, the number of moles and grams of salicylic acid and acetic anhydride can be answered.

Methods/ Material:
Capillary tube
TLC Plates
Gloves
250 mL, 600 mL beakers
Salicylic acid
Acetic anhydride
85% phosphoric acid
Buchner funnel
Hot plate
Filter paper
95 % of ethanol
FeCl3
Glass jar
Weigh approximately 1.5 g salicylic acid and record the exact mass.
Add 3.5 mL of acetic anhydride to it and add four drop …show more content…
For melting point technique, the pure acetylsalicylic acid melted between 130°C and 142°C, which was higher than the actual melting point of pure aspirin; 135°C. The phenol test showed that the product is not a pure aspirin by expressing purple color. TLC results weren’t high enough to conclude that the product was a pure aspirin. Overall, the lab wasn’t successful due to the low percentage of aspirin that were produced. Out of 2.0 grams of aspirin, only 0.7862 grams of pure aspirin were produced. So the percent yield was only 39%. Errors could be made during filtration process and the melting of the aspirin. These results showed that aspirin are not as pure as people
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