Antidepressants Review

Topics: Obesity, Antidepressant, Selective serotonin reuptake inhibitor Pages: 7 (2521 words) Published: August 28, 2013
Body weight changes: The use of antidepressants and diet pills.

Change in the body weight is a common effect of antidepressants substances use. Some studies based on antidepressant drugs have been done and they demonstrate that these medications can act as potential factors to increase or decrease weight. The tricycle antidepressant types such as amitriptyline are more likely to intensify and promote weight gain. On the other hand, substances like fluoxetine, paroxetine and sibutramine might lead to weight loss. There are many contrasts when it comes to the mechanism responsible for these variations in body mass. However, it is known that the weight rise can be the cause of different unwelcome future consequences such as type 2 diabetes mellitus, hypertension and other chronicle diseases. When it comes to weight decrease, the antidepressant drug problems are related to nervous system stimulation and it is at this point that the use of diet pills comes from. Most diet pills contain antidepressant constituents that have the power to act in the metabolism as thermogenic and in the activity of neurotransmitters increasing weight loss very quickly. This literature review will discuss the association between weight changes, antidepressant and diet pill intake and their consequences to users. In particular, it will relate the evidences and show the literature contrasts about the usage of antidepressants either as a medication or as a diet pill component.

Keywords: Tricycle antidepressants, Weight gain, Weight loss, Diet aids, Sibutramine

Antidepressants are some of the most prescribed/used medication all over the world (Batty, Geddes et al. 2010). These drugs can be used in many different situations such as depressive episodes, bipolar syndrome, eating disorders and others psychological and/or psychiatric conditions. Many side effects are associated with the use of antidepressants but changes on body weight are very common (Russ and Ackerman 1988). It has been studied and hypothesized as one of the causes of major depression episodes when combined with major changes on weight specially on cases of obesity or anorexia (Sutin and Zonderman 2012). There are different groups of antidepressants and they can lead into a diverse range of consequences in body metabolism and weight maintenance. The first generation of tricycle antidepressants is known to produce an increase in weight and the group of amitriptyline has it as permanent characteristic. (Joubert, Gagiano et al. 1995). On the other hand, there are other classes that usually have weight loss as an observed outcome such as Fluoxetine, Paroxetine and sibutramine that apparently have a small potential to reduce weight (Joubert, Gagiano et al. 1995). Due to this propriety, some antidepressant substances are included in diet pills (Cohen, McCormick et al. 2009). This can be very dangerous and end up increasing the contact with antidepressant among non-depressive patients (Cohen, McCormick et al. 2009). Especially women are affected by the use of diet pills because the concern about weight changes is more frequent in this group due to media pressure, pregnancy and the physiological characteristic to carry more fat mass on their body instead of the lean mass present on muscles (Sutin and Zonderman 2012).

Weight gain effect

One of the main concerns about prescribing an antidepressant drug is the potential side effect found in it. In particular, weight gaining as one of psychotropic drugs effects has been discussed and studied through the years and new researches have aimed to minimize and control this adversity. The main antidepressant group that causes body weight gaining is the tricycle and amitriptyline. A study conducted by Aberg in 1975 and cited by Gottifries in 1981, 204 patients were tested in three different kinds of psychotropic drugs, an increase of 83% in weight was noticed when compared to the placebo group. Also cited by Gottifries, in 1978 Coopen et...
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