Analysis Of Jatropha Gossypifolia Leaves

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7.10.2 Anti-implantation activity of isolated fraction of ethanolic extract Jatropha gossypifolia leaves
Female rats of proestrus phase were kept with male rats of proven fertility in the ratio of 2:1. The female rats were examined in the following morning for evidence of copulation. The animals were which showed thick clumps of spermatozoa in vaginal smear were separated from the male partner. Only the rats with normal estrous cycles were selected for the experiment. The animals divided into three groups of six animals each. The various groups were treated as follows:
Group I: control (saline solution) p.o.
Group II: ethanolic fraction of JG (200 mg/kg, p.o.)
Group III: ethanolic fraction extract of JG (400 mg/kg, p.o.)
The results are shown
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leaves exhibited significant antifertility activity against estrogenic and anti-implantation activity and other pharmacological screening models.
The aqueous extract at dose of 400 mg/kg had lesser activity then ethanolic extract at dose of 400 mg/kg, which exhibits more significant estrogenic activity with increase in uterine weight, when compared to control.
It is well known fact that estrogenic substances inhibit pregnancy by suppressing the level of both follicular stimulating hormone (FSH) and luteinizing hormone (LH), which in turn prevent the implantation. Estrogen and progesterone are the hormones responsible for histology and functional modifications of female genital tract (Uguru, et al., 1998). The exogenous administration of physiological doses of estrogen, in sexual immature rats, stimulated histoarchitecture of uterus (US Census Bureau, 2002). According to Laurence (Laurence and Bacharach 1964) any compound possessing estrogenic activity may exhibit antifertility activity; they act by suppressing gonadotrophin secretion, with consequent inhibition of ovulation. In immature female rats both ethanolic and aqueous extracts exhibited definite estrogenic activity in dose dependent manner (Uguru, et al., 1995). As supported by histological evidence the antifertility effect of aqueous extract at dose of 400 mg/kg may be due to increased height of luminal
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These extracts have shown dose and time dependent superoxide scavenging activity. Flavonoidal content was also found to be high in both of these extracts. Flavonoids are well known for antioxidant activity. This suggests that any drug/extract containing estrogenic property with flavonoids (non-steroidal phytoestrogen) might be better anti-fertile. Ethanolic extract with higher flavonoidal content was found to be more potent then aqueous extract. As well the activity is dose dependent which supports the role of non-steroidal phytoestrogen concentration. These observations tend to suggest that, ethanolic and aqueous extracts possess a significant estrogenic, in a dose dependent

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