Alzheimer's Disease Research Paper
Writing Assignment: Air Pollution and Alzheimer’s Disease
Read the Review Article: Air Pollution, Oxidative Stress, and Alzheimer’s disease
Paula Velencia Moulton and Wei Yang
Journal of Environmental and Public Health, Volume 2012
Address the following questions or statements in complete sentences and/or paragraphs. Do not copy or repeat excerpts from the article. Show independent thought and use your own words.
1. Describe Alzheimer’s disease and some of the clinical pathologies of the disease.
a. Alzheimer’s disease is a neurological disorder in which the death of brain cells can cause memory loss and losing the ability to learn. Some of the symptoms are worsened ability to remember new information. For example, asking getting lost …show more content…
There are two common risks factors that contribute to Alzheimer’s disease and that is APOE-4 alleles and cardiovascular disease. APOE-4 alleles are a class of apolipoprotein found in chylomicron and intermediate-density lipoprotein that is essential for the normal catabolism of triglyceride rich lipoprotein constituents. APOE-4 is the principal cholesterol carrier in the brain. Cardiovascular disease is heart and blood vessel disease. It is when plaque builds up in the walls of the arteries, making it harder for blood to flow through. Both APOE-E protein and impaired blood flow contribute to Alzheimer’s …show more content…
Air pollution includes ozone, particulate matter, carbon dioxide, and lead. The associating between air pollution like particulate matter and ozone can lead to oxidative stress causing AD pathology. Air pollution has been increasing due to environmental toxins. Air pollution is associated with respiratory and cardiovascular pathology especially in the aging population. To stop the oxidative stress the ROS is antioxidant defense mechanisms. ROS are important for maintaining oxygen homeostasis in tissues.
5. Describe what oxidative stress and explain why neurons are susceptible to oxidative stress.
a. Air pollution can contribute to AD because it enhances oxidative stresses processes causing physiological alteration in the central nervous system. If high levels of oxidative stress, the neurons are vulnerable to mitochondrial damage by free radicals. It will become irreversible in the brain because damage cells can be replaced.
6. Describe the macromolecules found within Alzheimer’s patients. Where are these macromolecules found in the patient?
a. Macromolecules found within Alzheimer’s patients are damage lipids, proteins, and nucleic acids, mitochondria and other cell compartments due to oxidative stress. Alzheimer’s patients are older because this process of damaging the mitochondria increases with
Read the Review Article: Air Pollution, Oxidative Stress, and Alzheimer’s disease
Paula Velencia Moulton and Wei Yang
Journal of Environmental and Public Health, Volume 2012
Address the following questions or statements in complete sentences and/or paragraphs. Do not copy or repeat excerpts from the article. Show independent thought and use your own words.
1. Describe Alzheimer’s disease and some of the clinical pathologies of the disease.
a. Alzheimer’s disease is a neurological disorder in which the death of brain cells can cause memory loss and losing the ability to learn. Some of the symptoms are worsened ability to remember new information. For example, asking getting lost …show more content…
There are two common risks factors that contribute to Alzheimer’s disease and that is APOE-4 alleles and cardiovascular disease. APOE-4 alleles are a class of apolipoprotein found in chylomicron and intermediate-density lipoprotein that is essential for the normal catabolism of triglyceride rich lipoprotein constituents. APOE-4 is the principal cholesterol carrier in the brain. Cardiovascular disease is heart and blood vessel disease. It is when plaque builds up in the walls of the arteries, making it harder for blood to flow through. Both APOE-E protein and impaired blood flow contribute to Alzheimer’s …show more content…
Air pollution includes ozone, particulate matter, carbon dioxide, and lead. The associating between air pollution like particulate matter and ozone can lead to oxidative stress causing AD pathology. Air pollution has been increasing due to environmental toxins. Air pollution is associated with respiratory and cardiovascular pathology especially in the aging population. To stop the oxidative stress the ROS is antioxidant defense mechanisms. ROS are important for maintaining oxygen homeostasis in tissues.
5. Describe what oxidative stress and explain why neurons are susceptible to oxidative stress.
a. Air pollution can contribute to AD because it enhances oxidative stresses processes causing physiological alteration in the central nervous system. If high levels of oxidative stress, the neurons are vulnerable to mitochondrial damage by free radicals. It will become irreversible in the brain because damage cells can be replaced.
6. Describe the macromolecules found within Alzheimer’s patients. Where are these macromolecules found in the patient?
a. Macromolecules found within Alzheimer’s patients are damage lipids, proteins, and nucleic acids, mitochondria and other cell compartments due to oxidative stress. Alzheimer’s patients are older because this process of damaging the mitochondria increases with