Alcoholism and Native Americans Essay

The continuous or excessive use of alcohol (ethanol) with associated pathologic results. Alcoholism is characterized by constant or periodic intoxication, although the pattern of consumption varies markedly. Individuals admitted for the first time to an alcoholism treatment center typically have been consuming 3–4 oz (80–100 g) of pure alcohol per day, corresponding to seven to nine drinks or bottles of beer or glasses of wine. Studies have shown that problem drinking in these populations starts at about 2 oz/day (60 g/day), that is, four to five drinks per day, and that these are consumed in rapid succession, leading to intoxication on three or more days per week. Individuals who consume these levels of alcohol have a greater-than-average risk of developing alcoholic liver cirrhosis. However, the levels should not be taken as absolute, since they can vary greatly in different individuals, according to body weight and other factors. |

The symptoms and consequences associated with severe alcohol consumption also vary greatly; that is, in some individuals only a few may be present. These may consist of the development of physical dependence manifested as a state of physical discomfort or hyperexcitability (tremors or shakes) that is reduced by continued consumption; the development of tolerance to the effects of alcohol, which leads individuals to increase their consumption; accidents while intoxicated; blackouts, characterized by loss of memory of events while intoxicated; work problems, including dismissal; loss of friends and family association; marital problems, including divorce; financial losses, including bankruptcy or continual unemployment. Medical problems can include gastric ulcers, pancreatitis, liver disease, and brain atrophy. The last is often associated with cognitive deficiencies, as shown by the inability to comprehend relatively simple instructions or to memorize a series of numbers. See also: Cognition |

Individuals seeking an early

Bibliography: * H. Bogleites and B. Kissin (eds.), The Genetics of Alcoholism, 1994 * Combine Study Group, Testing combined pharmacotherapies and behavioral interventions for alcohol dependence (the COMBINE study): A pilot feasibility study, Alcohol Clin. Exp. Res., 27(7):1123–1131, 2003 * J. C. Garbutt et al., Pharmacological treatment of alcohol dependence: A review of the evidence, JAMA, 281:1318–1325, 1999 [PMID: 10208148] * D. B. Goldstein, Pharmacology of Alcohol, 1983 * D. W. Goodwin, Alcoholism, 2d ed., 1994 * J. C. Hughes and C. C. Cook, The efficacy of disulfiram: A review of outcome studies, Addiction, 92:381–395, 1997 [PMID: 9177060] * F. Kiefer et al., Comparing and combining naltrexone and acamprosate in relapse prevention of alcoholism: A double-blind, placebo-controlled study, Arch. Gen. Psychiat., 60:92–99, 2003 [PMID: 12511176] * R. Z. Litten and J. P. Allen, Pharmacotherapies for alcoholism: Promising agents and clinical issues, Alcoholism Clin. Exp. Res., 15:620–633, 1991 [PMID: 1928636] * C. P. Rivers, Alcohol and Human Behavior: Theory, Research, and Practice, 1994 * J. R. Volpicelli et al., Effect of naltrexone on alcohol “high” in alcoholics, Amer. J. Psychiat., 152:613–615, 1995 [PMID: 7694913] | Additional Readings * H. L. Altshuler, P. E. Phillips, and D. A. Feinhandler, Alterations of ethanol self-administered by naltrexone, Life Sci., 26:679–688, 1980 * C. Brewer, Recent developments in disulfiram treatment, Alcohol, 28:383–395, 1995 * J. C. Froehlich et al., Naloxone attenuates voluntary ethanol intake in rats selectively bred for high ethanol preference, Pharmacol. Biochem Behav., 35:385–390, 1990 * C. L. Hubbell et al., Consumption of ethanol solution is potentiated by morphine attenuated by naloxone persistently across repeated administrations, Alcohol, 2:1–16, 1986 * M. Kornet, C. Goosen, and J. M. Van Ree, Effect of naltrexone on alcohol consumption during chronic alcohol drinking and after a period of imposed abstinence in free-choice drinking rhesus monkeys, Psychopharmacology, 104:367–376, 1991 * A. D. Le et al., The effects of selective blockade of delta and mu opiate receptors on ethanol consumption by C57BL/6 mice in a restricted access paradigm, Brain Res., 630:330–332, 1993 * H. R. Kranzler et al., Buspirone treatment of anxious alcoholics: A placebo-controlled trial, Arch. Gen. Psych., 51:720–731, 1994 * R. Malcolm et al., A placebo-controlled trial of buspirone in anxious inpatient alcoholics, Alcoholism Clin. Exper. Res., 16:1007–1013, 1992 * R. D. Myers, S. Borg, and R. Mossberg, Antagonism by naltrexone of voluntary alcohol selection in the chronically drinking macaque monkey, Alcohol, 6:383–388, 1986 * S. S. O 'Malley et al., Experience of a “slip” among alcoholics treated with naltrexone or placebo, Amer. J. Psych., 153:281–283, 1996 * S. S. O 'Malley et al., Naltrexone and coping skills therapy for alcohol dependence: A controlled study, Arch. Gen. Psych., 49:881–887, 1992 * S. S. O 'Malley et al., Six-month follow-up of naltrexone and psychotherapy for alcohol dependence, Arch. Gen. Psych., 53:217–224, 1996 * F. M. Paille et al., Double-blind randomized multicentre trial of acamprosate in maintaining abstinence from alcohol, Alcohol, 30:239–247, 1995 * H. Sass et al., Relapse prevention by acamprosate: Results from a placebo controlled study in alcohol dependence, Arch. Gen. Psych., 53:673–680, 1996 * M. A. Shuckit, Recent developments in the pharmacotherapy of alcohol dependence, J. Consult. Clin. Psychol., 64:669–676, 1996 * M. Soyka, H. Sass, and K. Mann, Acamprosate (calcium-acetylhomotaurinate) increases abstinence rate in weaned alcoholics—Results from a double-blind placebo-controlled study: Preliminary data, Alcoholism Clin. Exper. Res., 18:6–16, 1994 * J. R. Volpicelli et al., Naltrexone in the treatment of alcohol dependence, Arch. Gen. Psych., 49:876–880, 1992 * J. R. Volpicelli et al., Naltrexone in the treatment of alcoholism: Predicting response to naltrexone, J. Clin. Psych., 56:39–44, 1995. * C. Brewer, Recent developments in disulfiram treatment, Alcohol, 28:383–395, 1995 * H. R. Kranzler et al., Buspirone treatment of anxious alcoholics: A placebo-controlled trial, Arch. Gen. Psychiat., 51:720–731, 1994 * H. R. Kranzler and J. Van Kir, Efficacy of naltrexone and acamprosate for alcoholism treatment: A meta-analysis, Alcohol Clin. Exp. Res., 25(9):1335–1341, 2001 * K. Mann et al., The efficacy of acamprosate in the maintenance of abstinence in alcohol-dependent individuals: Results of a meta-analysis, Alcohol Clin. Exp. Res., 28(1):51–63, 2004 * S. S. O 'Malley et al., Naltrexone and coping skills therapy for alcohol dependence: A controlled study, Arch. Gen. Psychiat., 49:881–887, 1992 * S. S. O 'Malley et al., Six-month follow-up of naltrexone and psychotherapy for alcohol dependence, Arch. Gen. Psychiat., 53:217–224, 1996 * H. Sass et al., Relapse prevention by acamprosate: Results from a placebo controlled study in alcohol dependence, Arch. Gen. Psychiat., 53:673–680, 1996 * M. A. Schuckit, Recent developments in the pharmacotherapy of alcohol dependence, J. Consult. Clin. Psychol., 64:669–676, 1996 * M. Soyka, H. Sass, and K. Mann, Acamprosate (calcium-acetylhomotaurinate) increases abstinence rate in weaned alcoholics: Results from a double-blind placebo-controlled study: Preliminary data, Alcoholism Clin. Exp. Res., 18:6–16, 1994 * C. Streeton and G. Whelan, Naltrexone, a relapse prevention maintenance treatment of alcohol dependence: A meta-analysis of randomized controlled trials, Alcohol and Alcoholism, 36(6):544–552, 2001 * J. R. Volpicelli et al., Naltrexone in the treatment of alcohol dependence, Arch. Gen. Psychiat., 49:876–880, 1992 | Yedy Israel, Falk Kiefer, Steve Martino, "Alcoholism", in AccessScience@McGraw-Hill, http://www.accessscience.com, DOI 10.1036/1097-8542.021210