Age-Related Macular Degeneration

The age-related macular degeneration (AMD) is a disease that affects the elderly population with a incidence peak over 50 years old. It can occur in two main aspects: the wet form or the dry form. The dry AMD is characterized by the absence of choroidal neovascular complications with a less dramatic evolution compared to the wet form but no less disabling. Great challenge is to understand the pathophysiology that leads to development of one AMD form respect to another and within each of the two, the mechanisms that govern the evolution up to choroidal neovascularization for the wet AMD and to geographic atrophy (GA), that involves or not the macular region, for the dry AMD.
In the context of atrophy development, fits the dualism between the