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Acute Lung Injury: A Case Study

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Acute Lung Injury: A Case Study
BACKGROUND: Acute lung injury (ALI) is a one of severe manifestation and remains a major cause of morbidity and mortality in critically ill patients. However, protective mechanical ventilation is a current treatment of ALI that provides essential life support of critically ill patients, it leads to exacerbate lung functional and structural alterations. Mesenchymal stem cell (MSCs) based therapy is a promising and novel treatment, it has been considered to be a potential treatment of acute lung injury; however, the mechanism involved are barely understood. Glycogen synthase kinase -3β (GSK-3β) has been associated with the pathogenesis of several diseases. We hypothesized that, glycogen synthase kinase -3β (GSK-3β) may represent potential
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