Acute Leukemia Research Paper
Leukemia: a type of cancer with uncontrolled production of immature WBC (usually blast cells) in the bone marrow. (MS, 880). Characterized by the replacement of bone marrow by malignant immature WBC(148, Pearson)
Acute Leukemia: sudden onset, rapid progression & immature or undifferentiated blast cells (148 P)
Chronic Leukemia: gradual onset, prolonged course and abnormal mature appearing cells. (148 P)
Lymphoblastic/lymphocytic : involve immature lymphocytes & their precursor cells in the bone marrow. Infiltrate spleen, lymph nodes, CNS & other tissue. (P148)
Myeloid : involve myeloid stem cells in the bone marrow interfering with the maturation of all types of blood cells including granulocytes, RBCs and thrombocytes. (P148) …show more content…
Purpose is to achieve rapid complete remission of all manifestations of the disease. Consolidation: often consists of another course of either the same drugs used for induction at a different dosage or a different combination of chemo drugs. Maintenance: may be prescribed for months to years after successful induction and consolidation therapies.
Treatments for CML: Gleevec first line oral drug well tolerated & effective @ inducing remission for early stages of CML (884)
Treatment for CLL: chemotherapy can cause remission but does not cure the disease. Decision to initiate therapy is based on the stage, symptoms, and disease activity. (884) often requires no treatment ; chemotherapy, bone marrow transplant (149)
Drug therapies for AML: antibiotic & antibacterial drugs for prevention or treatment of infection (aminoglycoside Abx, penicillin or 3rd gen cephalosporins) systemic antifungals when fungal infection diagnosed or neutropenic patient is febrile for 4-7 days after ABx therapy. Antivirals to prevent & treat viral infections. (acyclovir) 884 chemotherapy, stem cell transplant
Acute Leukemia: sudden onset, rapid progression & immature or undifferentiated blast cells (148 P)
Chronic Leukemia: gradual onset, prolonged course and abnormal mature appearing cells. (148 P)
Lymphoblastic/lymphocytic : involve immature lymphocytes & their precursor cells in the bone marrow. Infiltrate spleen, lymph nodes, CNS & other tissue. (P148)
Myeloid : involve myeloid stem cells in the bone marrow interfering with the maturation of all types of blood cells including granulocytes, RBCs and thrombocytes. (P148) …show more content…
Purpose is to achieve rapid complete remission of all manifestations of the disease. Consolidation: often consists of another course of either the same drugs used for induction at a different dosage or a different combination of chemo drugs. Maintenance: may be prescribed for months to years after successful induction and consolidation therapies.
Treatments for CML: Gleevec first line oral drug well tolerated & effective @ inducing remission for early stages of CML (884)
Treatment for CLL: chemotherapy can cause remission but does not cure the disease. Decision to initiate therapy is based on the stage, symptoms, and disease activity. (884) often requires no treatment ; chemotherapy, bone marrow transplant (149)
Drug therapies for AML: antibiotic & antibacterial drugs for prevention or treatment of infection (aminoglycoside Abx, penicillin or 3rd gen cephalosporins) systemic antifungals when fungal infection diagnosed or neutropenic patient is febrile for 4-7 days after ABx therapy. Antivirals to prevent & treat viral infections. (acyclovir) 884 chemotherapy, stem cell transplant