012-Adrenoceptor Agonist Research Paper
History
The use of α2-adrenoceptor agonists in human medicine is not new and has been in practice for decades. In the early 1960’s, the first α2-adrenoceptor agonist was synthesized to be used as a nasal decongestant. Early application of the new substance, now known as clonidine, showed unexpected side effects, with sedation for 24 hours and symptoms of severe cardiovascular depression.[6] An imidazoline derivative Clonidine hydrochloride, after subsequent testing was introduced as an antihypertensive drug in 1966.[8] Veterinarians employed xylazine and detomidine to induce analgesia and sedation in animals since 1970.[8,9] DEX a 2nd generation α2 adrenergic receptor specific, pharmacologically active D- isomer of medetomidine was first synthesized
The use of α2-adrenoceptor agonists in human medicine is not new and has been in practice for decades. In the early 1960’s, the first α2-adrenoceptor agonist was synthesized to be used as a nasal decongestant. Early application of the new substance, now known as clonidine, showed unexpected side effects, with sedation for 24 hours and symptoms of severe cardiovascular depression.[6] An imidazoline derivative Clonidine hydrochloride, after subsequent testing was introduced as an antihypertensive drug in 1966.[8] Veterinarians employed xylazine and detomidine to induce analgesia and sedation in animals since 1970.[8,9] DEX a 2nd generation α2 adrenergic receptor specific, pharmacologically active D- isomer of medetomidine was first synthesized