01 Lecture chapter 00 01

Topics: Chemical equilibrium, Analytical chemistry, Chemistry Pages: 33 (2191 words) Published: April 19, 2015
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Analytical Chemistry
CHEM 2354

Analytical Chemistry
CHM 2354, Winter 2015
Schedule:
Monday LAB

14:30-18:30

Marion Hall (MRN)

Room: 301

Tuesday DGD
Thursday DGD
Thursday LEC
Tuesday LEC

14:30-15:30
14:30-15:30
08:30-10:00
10:00-11:30

HGN
FSS
Montpetit Hall (MNT)
Montpetit Hall (MNT)

Room: 302
Room: 2005
Room: 202
Room: 202

Instructor: Professor Maxim Berezovski
Office:
Address: D’Iorio Hall room 201
Phone: 613-562-5800 ext. 1898
e-mail: Maxim.Berezovski@uottawa.ca
web page: http://mysite.science.uottawa.ca/mberezov/
Office Hours:
15:30-17:30 Tuesdays & Thursdays (after DGDs) or by Special Appointment I am in my office many other times during the week and am always willing to speak with you if you find me in or make an appointment.

Introduction to Analytical Chemistry
Background
1.) Definition:
ANALYTICAL CHEMISTRY: The Science of Chemical Measurements.

2.) Types of Questions Asked in Analytical Chemistry
a.) What is in the sample? (qualitative analysis)
b.) How much is in the sample? (quantitative analysis)

3.) Techniques used in Analytical Chemistry:
a.) Wet Chemical Methods: titrations, color-forming reactions, precipitations, etc.
b.) Instrumental Methods: spectrometry, chromatography, mass spectrometry.

What is it ?
How much is there?
How pure is it?
What are the impurities?

The table shows the extent to which industrial employers
think students should have experience with various analytical techniques, as determined by the 2004 survey.

The Analytical Process
1.) Formulating the Question:
Translate General Question into Specific Question
Is this coffee strong?  What is the concentration of caffeine?

2.) Selecting Analytical Procedures:
a.) Choose procedure to measure caffeine

Sample preparation

Uncertainty in measurement

Limit of detection

Availability, time, cost
b.) If necessary, develop new procedure

3.) Sampling:
a.) Select representative material to analyze
(i) don’t use the entire sample
(ii) consistency in sample collection

Kazuki Yamamoto is a Japanese barista who 
constructs eye­popping works of 3D art using 
just foam and coffee.

Try Asking for One of These at Starbucks
Within the six years Yamamoto has been working at a coffee shop in Osaka, he's  racked up more than 100,000 Twitter followers obsessed with his latte art.

Sometimes One Cup Is Not Enough
Some of his creations even climb out of their cups and reach out to others ( I'm  afraid those fish are not long for this world…)

Introduction to Analytical Chemistry
The Analytical Process
4.) Sample Preparation:
a.) convert sample into form suitable for chemical analysis
(i) Remove species that interfere with analysis
(ii) Dissolve sample
(iii) Concentrate sample

Introduction to Analytical Chemistry
The Analytical Process
5.) Analysis:
a.) measure concentration of analyte in several identical
aliquots (portions)
(i) Replicate measurements  uncertainty in the
analysis



(ii)

Avoid large errors
Reliability of measurement

Calibration Curve


Measure response for known samples

6.) Report and Interpretation of Results
7.) Drawing Conclusions


How the Report is used

Introduction to Analytical Chemistry
The Analytical Process
4.) Sample Preparation:
a.) Example:

How do you prepare samples for Drug Discovery?

Cross-section of sacrificed
mouse showing tissue
removal

Inject mouse with
drug

Tissue plug from
mouse kidney

Chromatography indicates presence of
drug an metabolites in tissue sample

Determine drug quantity and distribution
Regulatory Toxicology and Pharmacology 31, S57–S62 (2000)

Units and Concentrations
To a large extent, analytical chemistry is a science of measurement and measurements require minimizing errors

Units of Measurement
1.) SI (International System of Units) from the French Le Système International d'Unités:
a.)...
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