“A COMPARATIVE CLINICAL STUDY ON THE THERAPEUTIC EFFECT OF VAITARANA BASTI AND YOGARAJA GUGGULU IN AMAVATA W.S.R. TO RHEUMATOID ARTHRITIS”
5. TITLE OF THE TOPIC STUDY:
“A COMPARATIVE CLINICAL STUDY ON THE THERAPEUTIC EFFECT OF VAITARANA BASTI AND YOGARAJA GUGGULU IN AMAVATA W. S. R. TO RHEUMATOID ARTHRITIS.”
6.BRIEF RESUME OF THE INTENDED WORK:
6.1. NEED FOR STUDY:
Amavata is a disease of vitiated vata associated with ama and it persists with multiple systemic involvements mostly affecting the bony joints. The disease starts with minor symptoms, but may develop and extend to all over the body wherever ama is going to get lodged along with vitiated vayu.As the disease progresses addistional symptoms with complications like kanja, pangulya etc may be seen1.
Rheumatoid arthritis presents with more similar features of Amavata vyadhi. It exhibits either as oligo or poly arthritis with symmetrical involvement along with inflammation, stiffness, tenderness etc. As the disease advances contracures are produced leading to deformity of affected joints like Swanneck deformity, Z deformity etc. It is also a troublesome long persisting disorder having articular as well as extra articular signs and symptoms, yielding socio economical problems and unable to have self care even. As per the data available 5% of the total population of the world is said to be affected with crippling disorder. It is estimated that females are affected three times that of the males usually manifests from 30-50 years of life2.
A number of treatments established so far, the disease it self being yapya may not respond satisfactorily. The patient has to inevitably suffer for a long time. Hence an effort has to be done to compare the effect of Vaitarana basti and Yogaraja guggulu which may be a promising step in the approach of Amavata vyadhi3.
6.2 REVIEW OF LITERATURE
The disease Amavata considered to be existing long back. Madhava nidana is the first text which introduced and elaborately explain concept of Amavata being a separate disease. Chakradatta contributed effective line of treatment in his text. Later Bhavaprakasha4 added few medicines in the form of churna, vati, kashaya. Some additions are also seen in Sarangradhara5, Bhaishajyaratnavali6, Yogaratnakara7, etc. Though Amavata is not directly considered being separate disease in Samhitas, still some of the therapeutic list of indications included Amavata by Charaka Samhita. Treatment of sarvashariragata Ama resembles that of Amavata vyadhi8. Mentioning of Yogaraja guggulu being an effective Shamanoushadi is seen in Bhaishajya ratnavali9, Yogaratnakara10, Bhavaprakasha11.Vaitarana basti is considered to be effective remedy as mentioned in chakradatta12.
PREVIOUS WORK DONE
1. A single blind clinical study in which 20 patients suffering from Amavata were given Shiva guggulu for 28 days in a dose of 500mg 2 tab t.i.d. Results shown as Shiva guggulu was more effective in acute condition than in chronic stage13. 2. A single blind comparative clinical study in which 30 patients suffering from Amavata were randomly grouped into two, where one group was given with Haritaki guggulu for 28 days before half an hour prior to food in the dose of 500mg 2 tab t.i.d. and control group was administrated with single dosage of Navaka guggulu only of 30 days with Luke warm water. Results showed 2 patients in each group had 100% relief from symptoms. The study shows both drugs are having equally efficient14. 3. Permkishor - Rheumatoid arthritis (amavatha) w.s.r to its pathogenesis and treatment with an indigenous drug15. 4. Varma M d study of posology and drug toxicity w.r.s to dalbergia lanceolara(gaurakha) in the treatment of rheumatoid arthritis 16.
6.3 OBJECTIVES OF STUDY:
1. To evaluate the efficacy of Yogaraja guggulu alone in Amavata. 2. To evaluate the efficacy of Yogaraja guggulu after Vaitarana basti in Amavata. 3....
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