Phantom limb pain is a common symptom experienced by over 90% of amputees. It’s defined as a painful sensation from a part of the body that no longer exists. There are a variety of methods for treating this neuropathic pain, but at the moment there is no specific treatment to tackle the pain completely. A mixture of medications and therapies has been proposed and trialed including drugs, surgical treatment and neuromodulation. Nonetheless, it is essential that a specific mechanism is targeted to in order to achieve the best therapeutic method.…
Carpal Tunnel Syndrome (CTS) also called median nerve compression is a very common injury to the hand and wrist that causes numbness and tingling. More than 3 million cases of Carpal Tunnel Syndrome are reported each year in the United States . The carpal tunnel is a passageway from your wrist to your hand that consists of bones, tendons, ligaments, and the median nerve. The median nerve that passes through this tunnel is responsible for delivering sensations to the thumb, index finger, middle finger, and the thumb side of the ring finger . The pathology of this injury is believed to be due to compression, entrapment, or irritation of the median nerve. Anything that may cause a reduction in the narrow space of the carpal…
I believe there has been peripheral nerve damage because of the symptoms that he exhibits. It seems that his receptors are not effectively communicating back to the central nervous system; in addition he is losing his somatic reflexes in his feet, both indicating damage to his somatic nervous system. I guess there could be damage to the central nervous system, but I would expect that the symptoms would be even more severe.…
J. Nick’s symptoms indicate a peripheral polyneuropathy rather than a CNS lesion of the brain or spinal cord because they are symptoms related to sensation loss or weakness of certain areas.…
For regeneration of neurons (getting sensory feeling back), his type of injury involves the PNS neurons that were involved, rather than CNS neurons, so the chances of his neurons regenerating increase.…
Inflammatory lesions scattered throughout the peripheral nervous system Circumscribed areas of myelin loss associated with presence of lymphocytes and macrophages Initial lesion: nodes of Ranvier Myelin damage: penetration of macrophages into basement membrane around nerve fibers & strip myelin away Severe cases: interruption of axon & wallerian degeneration…
1.What is the Glasgow Coma Scale? The Glasgow Coma Scale (GCS). The GCS is an objective assessment that defines the level of consciousness by giving it a numeric value…
Kathy, a 20-year-old woman, awakens one morning to a tingling, numb sensation covering both of her feet. This has happened to her a number of times throughout the year. In the past, when experiencing this sensation, within a couple of days to a week the numbness would subside, and so she is not too concerned. About a week later, she…
by cutaneous stimulation of the nerve. Ptosis, loss of taste, and facial weakness are not…
Complications such as sores, ulcers, or infections. Also there are no medications currently available to treat the underlying cause of peripheral neuropathy. Current treatments for type 1 diabetes focus on replacing insulin, but not replacing C-peptide. However doctors are now learning more about C-peptide and its role in diabetes-related complications. When C-peptide…
Congenital Insensitivity to Pain with Anhidrosis (CIPA) is an extremely rare hereditary disease with many side affects. This life threatening disease is so scarce that, according to reports, there are only seventeen to thirty-five occurrences in the United States, with approximately one hundred cases reported around the world. CIPA belongs to a family of Hereditary Sensory and Autonomic Neuropathies (HSAN). It is also known as HSAN IV. The disease affects individual’s autonomic, sensory, and motor functions. CIPA arises through a mutation in the TrkA gene which directly affects the nerve growth factor (NGF). NGF allows humans to feel the sensations of intense heat, freezing cold, and/or pain. Without such feelings, people with CIPA usually appear fearless or insane. They may play in the snow in a t-shirt, drink boiling tea, or walk on broken feet without the slightest notion that something is amiss. Their bodily temperature can be raised to the point of heatstroke by just moving around or playing a game, so the persons affected by this terrible disease must stay out of direct sunlight and keep their temperature down between sixty-eight and seventy-two degrees. Their lack of sweating gives them a thick, rough, and almost leathery skin that makes them more prone to infections…
Before participating in this contrived experience, I did not expect my involvement to impact me as much as it did. After simulating monocular vision, due to Arteritic Anterior Ischemic Optic Neuropathy (NAAION), I realized that I undeniably take completing my activities of daily living for granted. This experience has made me appreciate my capabilities more. Focusing in class, studying, and grocery shopping were some activities that I had the most difficulty with. Overall, I learned how to be more empathetic towards an individual who might actually be affected by this disability.…
On the other hand, patients with diabetes can present later with more severe diseases. Treatment of patients with a Peripheral Artery Disease has 2 components: management of Peripheral Artery disease and cardiovascular risk reduction. Patients with PAD should receive treatment that include antiplatelet agents, lipid-lowering therapy, antihypertensives, smoking cessation therapy and improved glycemic control. On the other side, Patients who have both PAD and diabetes require the similar treatment but the difference is that patients with Type 2 Diabetes and PAD need to get special consideration because of the high-risk status. For example, LDL cholesterol and blood pressure targets are more aggressive in diabetic patients compared to other patients groups. In addition, patients with diabetes need to regularly get their foot checked/inspected and get the optimal foot care because diabetes increases the risk that critical limb ischemia will develop and severe lesions possibly could get remain undetected as a result of neuropathy.…
Charcot-Marie-Tooth disease (CMT) also known as Hereditary Motor Sensory Neuropathy (HMSN) is a genetic heterogeneous disorder with a common clinical phenotype. It’s the most common inherited neuromuscular disease, with there being 200,000 cases in the EU (Pareyson and Marchesi, 2009). CMT is a group of diseases that affect the periphery nerves in the body, motor and sensory nerves are affected however in some rare cases only the motor nerves are affected; distal hereditary motor neuropathy (dHMN). The affected nerves cause characteristics such as muscle weakness and lack of sensation in the respective limbs. It can be characterised by there being no known metabolic derangement with the inherited neuropathy. It’s caused by mutations in particular…
Lyrica is FDA approved to treat pain from damaged nerves (neuropathic pain) that follows spinal cord injury…