Pathophysiology of Liver Cirrhosis

Chronic Alcoholism
(started drinking half gallon of tuba every day at the age of 16, beer and redhorse 2-3 times a week)
Chronic Alcoholism
(started drinking half gallon of tuba every day at the age of 16, beer and redhorse 2-3 times a week)
Liver Cirrhosis
Liver Cirrhosis
Risk Factors * Chronic alcoholism * Smoking * Diet Malnutrition
Risk Factors * Chronic alcoholism * Smoking * Diet Malnutrition
Predisposing Factors * Age > 45 y/o * Gender (more common in male) * Asian
Predisposing Factors * Age > 45 y/o * Gender (more common in male) * Asian

Chronic inflammation due to Helicobacter pylori
Chronic inflammation due to Helicobacter pylori

Adaptive increase in enzymes
Adaptive increase in enzymes

Liver cells became inflamed
Liver cells became inflamed
Inflammation of the lining of the stomach
(gastritis)
Inflammation of the lining of the stomach
(gastritis)
Contributing factors for hiatal hernia * Farmer (heavy lifting or bending) * smoking
Contributing factors for hiatal hernia * Farmer (heavy lifting or bending) * smoking

Ampicillin
Causes chronic active gastritis
Defect in gastrin regulation
Increased acid
H. pylori responses to increased gastrin
Contributes to erosion of mucosa
Ulcer formation
Gastric ulcer
Gastrointestinal bleeding
Causes chronic active gastritis
Defect in gastrin regulation
Increased acid
H. pylori responses to increased gastrin
Contributes to erosion of mucosa
Ulcer formation
Gastric ulcer
Gastrointestinal bleeding

Increased production of lipoproteins
Increased production of lipoproteins

Increased pressure on the abdomen
Increased pressure on the abdomen

Necrosis of hepatocyte
Necrosis of hepatocyte

Nausea, vomiting,
Pernicious anemia
Nausea, vomiting,
Pernicious anemia
Hyperlipidemia
Hyperlipidemia

Protrusion of the upper part of the stomach
Protrusion of the upper part of the