Topics: Bacteria, Pneumonia, Pseudomonas aeruginosa Pages: 7 (1107 words) Published: October 9, 2013

1. What is the causative organism (genus and species) for the disease? Legionella pheumophilia

Family Pseudomonacea:
Pseudomona aeruginosa
Family Pasteurellaceae
Haemophilus influenza

Bordetella pertussis
2. Is the causative organism a virus, bacterium, protest, mold or yeast? Bacteria
3. General characteristics.

Morphology: Bacilli pleomorphic-( cocci ->filaments) varies Motility: flagella
Gram reaction: gram negative
Requirement growth: aerobe
Opportunistic Pathogen
Requires special media( charcoal yeast extract) or cell culture Hard to gram stain
Morphology: bacilli
Motility: flagella
Gram reaction: gram negative
Requirement growth: aerobe
Oxidase positive
Catalase positive
Produce pigment(soluble-green)
Metabolically versatile
(Synthesize an unusually large number of enzyme and metabolize a wide variety of substrates) P. aeruginosa
Opportunistic pathogen
Resistant to many disinfectants(This resistance is probably related to the characteristics of the cell wall porins which regulate the entrance of molecules through the cell wall) common contaminant in hospital (responsible for about one in ten nosocomial infections, especially among infections in burn units and the ability to growth on minute trace of unusual carbon sources such as soap residue or cap-liner adhesive found in a solution) Often resistant to many antibiotics(The large genome of pseudomonas also codes for several very efficient efflux pump systems that eject antibiotics from cell before they can function) Morphology: Pleomorphic bicilli

Motility: non-motile
Gram reaction: gram negative
Requirement growth: facultative anaerobe
Fastidious (do not survive in surface very long)
It was the first cause of meningitis before vaccine
Requires X & V factors for growth (due to their inability to synthesize important parts of the cytochrome system needed for respiration: obtain these substances from the heme fraction) Sensitive to drying disinfectants, antibiotics(+)

Most strain are opportunist pathogens

Morphology: small bacilli
Motility: non-motile
Gram reaction: gram negative
Requirement growth: aerobe
4. Infection dose
3-30% high mortality

5. Important virulence factors.
- Poring protein involved in attachment (rather than being phagocyte) -Survive and multiply in phagocytes and release through cell lyses. (macrophages), * Its ability to survive and reproduce within aquatic amoeba often makes them difficult to eradicate in water systems. *Resistant to chlorine than most other bacteria and can survive for long period in water with a low level of chloride. -Endotoxin

-Degradation enzymes
-Endotoxin-this lets to the build of mucus
-Pertussis toxin (exotoxin),
-Tracheal toxin (exotoxin), -Adherence (attachment to respiratory cilia) 6. Reservoir for the microbe.
Fresh water living intracellular in Amoeba ( thrives in temperatures 25-45C of air-conditioning cooling towers and water supply lines) Free-living Soil and hot water(grow and reproduce on sinks, flower vases, mop water, dilute disinfectants) Human, usually healthy adult carriers

Infected human
7. Primary mode of transmission for the microbe/disease(s).
Vehicle transmission via aerosols (airborne)
Non-communicable (from person to person)
Vehicle transmission (waterborne)
Direct contact transmission with the carrier human
Direct contact with discharges from respiratory mucous membranes (coughing and by nasal dripping) Contagious!
8. Disease cause by the microbe
-Nosocomial infection
-Legionnaire’s disease (more severe form of the infection and produces pneumonia) -Pontiac Fever (milder respiratory illness w/o pneumonia)
-Nosocomial infections Urinary tract infections indwelling catheters(growth in dense biofilms that contribute to its frequent identification as a cause of...
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