alkanes

Topics: Chemistry, Formative assessment, Pharmacy Pages: 12 (3244 words) Published: October 28, 2014
The Leicester School of Pharmacy
Faculty of Health and Life Sciences

PHAR1603
Pharmaceutical Chemistry

Module Handbook 2014-15

The Leicester School of Pharmacy

MPharm (Hons)

The Module Team
Room

Email address

Phone (0116 …)

Dr G Hall (GH, Module Leader)

HB2.25n

ghall@dmu.ac.uk

257 7278

Dr P Bremner (PB)

HB1.03

pbremner@dmu.ac.uk

257 7922

Dr J Dixon

HB1.16

jdixon@dmu.ac.uk

207 8117

Prof. Katherine Huddersman (KH)

HB2M1

huddzeo1@dmu.ac.uk

257 7134

Dr E Jaroszkiewicz (EMJ)

HB2.16

emj@dum.ac.uk

257 7273

Dr M Wang (MW)

HB2M6a

mwang@dmu.ac.uk

257 7115

Dr S Pickering (SP)

HB2.03

spickering@dmu.ac.uk

250 6274

Dr D Sillence (DS)

HB2M2

dsillence@dmu.ac.uk

250 6368

Dr K McKechnie (KMcK)

HB1.16 kmckechnie@dmu.ac.uk

207 8117



If you wish to see a member of staff outside of class, you should try wherever possible to make an appointment. Due to their other commitments, staff may be unable to see you if you turn up unannounced at their offices.



It is also possible that some members of staff may move office for a variety of reasons. Therefore it is best to email them first unless it is urgent.



You must use your DMU email account for any correspondence; this is the account staff will use if they need to contact you therefore it is essential that you check your DMU email on a regular basis.



In the same vein, it is important that you do not leave any queries until the “last minute”, such as waiting until the day before an assignment is due to be submitted before seeking assistance with it. As a practising pharmacist, you must be well organised and be able to plan your work well – the module team aims to help in preparing you for this role.

PHAR1603

1

Pharmaceutical Chemistry

The Leicester School of Pharmacy

MPharm (Hons)

Module Characteristics
The aim of this module is to give you an understanding of aspects of chemistry relevant to Pharmacy. This will provide a knowledge basis for further study of the science that underpins the practice of Pharmacy.

Outline content
The content will follow four themes.







Inorganic chemistry related to the structure of atoms and thus molecules, from this the role of ions in biological systems will be studied, e.g. iron in haemoglobin and drug metabolising enzymes
Organic chemistry relating to the structures of drugs and biologically important molecules, paying particular attention to how the structure of drugs influences their biological activity, formulation and analysis, e.g. the prediction of solubility of drugs based on recognition of the ability of a drug to ionise at certain pHs, the possibilities of incompatibilities in infusion fluids.

The structure and function of the major groups of biochemicals leading on to cellular metabolism, including disease states/drug discovery opportunities Introduction to analytical chemistry including the role of the British Pharmacopoeia in ensuring patient safety and the quality of medicines.

Links between the themes will be developed, for instance between the structures of biochemicals and the chemical stucture of their constituent parts. Connections with other parts of the programme will also be signposted. For instance the nomenclature of anti-fungal drugs is based on the their chemical structure e.g. clotrimazole as found in Canestan is an imidazole whereas fluconazole is a triazole, see problem based learning in PHAR 1605.

N

N

N
H

imidazole

N

Cl

N

N
N

N

H
1,2,4-triazole

N

N
N

N

N
OH

F
F

fluconazole

clotrimazole

Many drugs are either weak acids or weak bases and given as salts. Pharmacists must be able to calculate equivalent doses.For instance morphine is given as the sulfate salt in

PHAR1603

2

Pharmaceutical Chemistry

The Leicester School of Pharmacy

MPharm (Hons)

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