• Ms.
    percent recovery for the recrystallization products. The amide synthesis product gave a recovery yield of 67.2%, where as the product from the Williamson Ether synthesis gave a recovery yield of 83.53%, despite the fact that the same exact method and solvent, boiling water, where used for both...
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  • Synthesis of Acetophenetidin
    Purpose Acetophenetidin can be formed through two methods, Williamson ether synthesis and amide synthesis. By working in groups of two we were able to complete both methods of synthesis routes. The end result should be the synthesis of a similar product, by verification between the two...
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  • Williamson Ether Synthesis of Phenacetin
    . Discussion: Sodium ethoxide (NaOEt) was used to react with acetaminophen. An alternative procedure would include use of weak base potassium carbonate (K2CO3, pKa = 10.3). K2CO3 is anhydrous, and the Williamson ether synthesis majorly involves the removal of a proton from an alcohol using an SN2...
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  • Synthesis of Acetophenetidin by Amide Synthesis
    The goals of this experiment are to determine if the products derived from amide synthesis and Williamson Ether Synthesis are identical, and if one of the synthetic routes is more advantageous than the other. In Part 1, an attempt to synthesize acteophenetidin crystals by amide synthesis was made...
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  • Chemical properties of The and it's derivatives
    as anandamide (20:4, n-6). The synthesis of AEA analogs with amide modifications in the head group was achieved from arachidonic acid using either the acid chloride, carbodiimide, mixed anhydride, active ester procedures10,67-69 or from the ester of arachidonic acid with a cyanide catalyzed...
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  • Orgo 1 Study Guide
    towards nucleophiles. They will react with nucleophiles under both acidic and basic conditions. However the patterns are different. The Williamson Ether synthesis: alcohol, base, alkyl halide (or tosylate) masterorganicchemistry.com Sept 2012. Version 1.1 H + ! O O H + ! more...
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  • Reagents for Interconverting Carboxylic Acids and Acid Derivatives
    a +.  The C-O-C bond angle is 111o, slightly higher than the H-O-H bond angle in water because of the stronger electron repulsion between the bulky alkyl groups. Preparation of Ethers: 1. Preparation of symmetrical ethers from alcohols H2SO4 R O R + H2O 2ROH  2. Williamson Ether Synthesis...
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  • Grade 12 Chemistry Exam Prep
    group (OH ). The OH is always given the lowest number possible and must be included in the bigger chain. Ex. Primary: Secondary: Tertiary: Synthesis of Ethers: Ethers general formula: R-O-R The largest carbon chain is considered the parent chain; the shorter chain is given the...
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  • phenols
    convert aromatic sp2 C-H bonds into C-O bonds. G.-W. Wang, T.-T. Yuan, X.-L. Wu, J. Org. Chem., 2008, 73, 4717-4720. A palladium-catalyzed synthesis of aryl tert-butyl ethers from a variety of unactivated aryl bromides or chlorides is described. The ether products, which are precursors to phenols...
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  • Organic Chemistry
    following reaction Concd. HBr (xs) C6H5CH2OCH3 A) B) C) D) E) ? heat C6H5Br + CH3OH C6H5CH2Br + CH3Br C6H5CH2OH + CH3Br C6H5CH2Br + CH3OH C6H5CH2CH2Br Ans: B Topic: Ether Synthesis 27. A) B) C) D) E) Which is the best way to prepare 3-methoxypentane via the Williamson...
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  • Ionic Liquids
    field of ongoing primary research. 2.3 Synthesis 2.3.1 Alkylation Alkylation reaction is the transfer of an alkyl group from one molecule to another. The alkyl group may be transferred as alkyl carbocation, a carboanion, a free radical, a carbene or their equivalents. Alkylating agents are...
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  • Hydocarbon Molecular Formula Structural and Uses
    industrially for removing carbon dioxide (CO2) and hydrogen sulfide (H2S) from natural gas and refinery process streams. They may also be used to remove CO2 from combustion gases / flue gases and may have potential for abatement of greenhouse gases. Related processes are known as sweetening.-Amides are...
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  • Basic Organic Chemistry
    (a) CH3CCH 2CH 3 (b) CH 2NCH 3 (c) CH3CH 2CH 2OCH OCH 3 8.34 Williamson Synthesis of Ethers: Sections 8.4A and 8.6 T he halogen can be Cl, Br, or I. (a) CH3CH 2CH 2ONa + CH3CH 2Cl (b) CH 3 CH 3 CHONa CH 3CH 2CH 2OCH 2CH 3 + NaCl CH 3 CH 3 CHOCH 2CH 3 + NaCl + CH 3CH 2Cl...
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  • Michael Addition
    structural diversity and complexity of the oxazoles has generated much interest in the development of mild methods for their synthesis.7 Recently, some 2,4-disubstituted oxazoles were prepared by the oxidation of the oxazolidine formed from the direct condensation of serine with aldehydes.8 2,4,5...
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  • Acetinalide Report
    solution, nitrous acid converts aniline into a diazonium salt that is an intermediate in the preparation of a great number of dyes and other organic compounds of commercial interest. When aniline is heated with organic acids, it gives amides, called anilides, such as acetanilide from aniline and...
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  • Acyclic Hydrocarbons
    scientific philosophy back then was that the synthesis of organic compounds could only be produced within living matter | |while inorganic compounds were synthesized from non-living matter. A theory known as "Vitalism" stated that a "vital force" from | |living organisms was necessary to make an...
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  • Organic Chemistry!
    molecule is joined with the acid end of another molecule, a molecule of water is eliminated. The process of removing water is sometimes referred to as dehydration synthesis. The result is a longer molecule made from two amino acids linked by an amide bond. This particular type of bond is known as a peptide...
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  • Photochemistry
    , the reaction is generally performed in ether solvents at low temperature. O R or O R R' R H LiAlH4 R OH or H OH R' O Br Me LiAlH4 Et2O, -78 C Scheme 3 OH Br Me Mechanism The hydride from LAH is transferred to the carbonyl group to form alkoxy anion which then forms complex with...
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  • Effect of Organic Solvents
    - Increased thermal stability of the enzyme - Facilitated transformation of substrates unstable or poorly soluble in water - Synthesis of ester or amide bonds by hydrolases - Prevention of side reactions due to water - Modification of enzyme selectivity Possible causes of lower enzymatic...
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  • Organic Chemistry
    , synthesis, and reactions of alcohols and ethers, and then you get to tackle conjugated unsaturated systems. Finally, we remind you of spectroscopic techniques, from the IR fingerprints to NMR shifts. The review in this part moves at a pretty fast pace, but we’re sure you can keep up. P In...
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