• Difference in Lymphatic Function in Health and Disease State
    QUALITY EVALUATION OF PARACETAMOL IN THE BULK, DOSAGE FORMS AND BODY FLUIDS USING THE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC) TECHNIQUE S. Asare-Nkansah and J.K. Kwakye Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science...
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  • Niper
    used to determine muscle relaxant property of any drug in mice(eg Diazepam) .catalepsy: it is a condition cherecterised by loss of consciousness with rigidity of muscles that keep limbs in fixed condition( haloperidol is used to induce catalepsy during animal experimentations) .PA2 value: defined...
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  • Pharmacology Questions
    of clowns… GP13 [k] Therapeutic index: A. Easy to determine in humans – No - how many humans do the ethics committees allow you to kill? ☺ B. ? C. D. E. Derived from LD50/ED50 – Yes, the ratio of the two In that order GP14 [k] (A Basic drug with a pKa of 8.7) A. ? B. ? C. Will be predominantly ionised...
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  • Chemistry Lab
    The pKa of an Unknown Acid-Base Indicator By: Josephine Hong Lab Instructor: Yue Zhang Due: April 5, 2013 Submitted: April 5, 2013 Abstract: In this lab, the pKa of the unknown indicator of expression was determined both qualitatively and quantitatively. To verify our procedures, the experiment...
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  • Ph and Buffer Solution
    experiment was carried out to determine the role of buffer solution and the factor which affect the buffer capacity. Besides, this experiment was carried out to investigate the solubility of protein casein over a range of pH concentration. This experiment also was carried out to determine the isoelectric point...
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  • Chem 3418 Organic Chemistry Laboratory I Acid Base Review
    incorporates the concentration of water as a constant value. Ka = [ H3O+][A-] [HA] and Ka = Kd [H2O] Organic acid ionization constants can cumbersome to work with because they are often very small numbers. Acetic acid, for example, has a Ka is value of about 0.00001 (or 10-5), phenol has a Ka of...
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  • Acids and Bases
    acid was determined by potentiometric titration. In the first titration, a strong acid standard, potassium hydrogen phthalate (KHP), was used, to determine the concentration of a strong base, sodium hydroxide (NaOH). In order to do so, we prepared NaOH solution, prepared a buret, and standardized this...
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  • Determination of an Unknown Amino Acid from Titration
    curve to determine the identity of an unknown amino acid. The initial pH of the solution was 1.96, and the pKa's found experimentally were 2.0, 4.0, and 9.85. The accepted pKa values were found to be 2.10, 4.07, and 9.47. The molecular weight was calculated to be 176.3 while the accepted value was found...
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  • The Determination of Acid Constant Ka
    the student to the concept of a primary standard and the process of standardization. From my graph my equivalence point was PH=8.80, volume is 15 ml , pka=4.80, ka=1.58 × 10-5 Introduction Acids dissolve in water with dissociation and the formation of hydrogen ions. According to the equation HA(aq)+H2O(l)-------H3O+(aq)+A-(aq)...
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  • Histidine Titration Lab
    amino acid Acidic amino acid Basic amino acid 7 OH- equivalents Objectives: A) To determine the titration curve for an amino acid and B) to use this curve to estimate the pKa values of the ionizable groups of the amino acid and the amino acid’s pI. Introduction: A titration curve...
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  • Chemistry 151 Weak Acid Titration
    Weak Acid Titration Abstract: Our method for determining the unknown weak acid was to determine the equilibrium constant K from the molecular weight of the weak acid from our titration data. In this lab the acid Potassium hydrogen phthalate and two unknown acids were titrated. We determined the molar...
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  • Chem I: Identification of unknown acid
    experiments to determine the equivalent weight, melting point, and pKa values of the RCO2H, the unknown acid 251547-BS13 can be identified. Through experimentation, the equivalent weight of RCO2H was determined to be 83.06 g/mol. A 200-202 °C melting point, 3.00 pKa1, and 4.50 pKa2 values were also determined...
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  • Synthesis of an Organic Acid
    Medhen Shekay Harrisetta Sandoval CHM 112 01 April 2013 Determining the pKa of an Unknown Acid Abstract: Within this laboratory experiment acetic anhydride and salicylic acid were reacted using phosphoric acid to speed up the process. The purpose of this laboratory experiment was to identify and...
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  • Structural and Electronic Effects Acids and Bases
    ACID STRENGTH pKa - An alternative to Ka to describe acid strength. (A concise way to state the strength of an acid.) electron pair is not removed from the Lewis base. Instead, it is donated to an atom of the Lewis acid and one new covalent bond is formed. 5 1 Acid Strength and pKa • Acid strength...
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  • Physicochemical Properties of Local Anaesthetics
    hydrophilic component separated by an intermediate chain (Walton et al., 1994). The linkage between hydrophilic and hydrophobic groups that each possesses determines which chemical groups, ester, or amides, they fall into. Amides, which are now more commonly used, as esters are comparatively unstable in solutions...
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  • Spectrophotometric Determination of the Acid Dissociation Constant of Methyl Red
    experiment aims to determine the acid dissociation constant value of Methyl Red by means of spectrophotometry. Ten samples were spectrophotometrically analyzed under a UV-Vis spectrophotometer and from the absorbance values acquired, calibration curves were constructed to determine the concentration of...
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  • Chemistry Lab Report 2
    swirled and inverted the flask until all the KHP is dissolved into the H2O. KHP+H2O-------H3O+ + KP- In our second part of our experiment to determine the molarity of NaOH, we rinsed a burette with about 5ml of water and another 5ml of NaOH to prepare it for the experiment. We then measured exactly...
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  • Determine Pka of Ethanoic Acid
    Determining the pKa value for ethanoic acid Part 1: Determining the concentration of a solution of sodium hydroxide Method: 1. A clamp stand was set up to hold a burette, previously washed with distilled water and filled with sodium hydroxide solution of approximately 0.1moldm-3. The pH meter...
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  • Biochemistry Essay
    pH meter and construct a titration curve of an amino acid to determine the pka values of its ionisable groups to identitfy an unknown amino acid. Method: The ratio of [HPO42-] to [H2PO4-] required to produce buffer solutions at pH values 5.9, 6.9 and 7.9 were calculated. 0.1M of H2PO4- and 0.1M HPO42-...
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  • Synthesis of Asa
    in 50-mL Erlenmeyer flask. Obtain the weight of the dried product and compute for the %yield. Measure its melting point and compare it to literature value. Give the chemical equations involved in the synthesis of salicylic acid. Waste Disposal: Neutralize any acid in the filtrate using aqueous sodium carbonate...
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