• Difference in Lymphatic Function in Health and Disease State
    HPLC has been used to determine paracetamol in tablets. Franeta et al (2002) used the HPLC for the 19 simultaneous determination of acetylsalicylic acid, paracetamol, caffeine and phenobarbital in tablets on a reversed-phase column using a mixture of acetonitrile and water (25:75 v/v...
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  • Niper
    molecule take about 12 to 15 years to reach the patients and the cost of us$ 400 to 650 million. -Read birch reduction reaction Animal models: .Rotarod apparatus: used to determine muscle relaxant property of any drug in mice(eg Diazepam) .catalepsy: it is a condition cherecterised by loss of...
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  • Pharmacology Questions
    up to one year of age:1 g/kg - Children 1 to 12 years of age:25 to 50 g - Adolescents and adults:25 to 100 g (A) could be the ‘most correct’ answer given this bunch of clowns… GP13 [k] Therapeutic index: A. Easy to determine in humans – No - how many humans do the ethics committees allow you to kill...
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  • Chemistry Lab
    ). For bromocresol green, the experimentally obtained pKa value measured qualitatively was 4.04. Quantitatively, the pKa came out to be 4.16. The percentage error (10.47%) obtained was within reasonable range, allowing the same procedures to be used to determine the pKa value of the unknown indicator...
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  • Ph and Buffer Solution
    ]) = pKa + log ([acetate ion])/([aceic acid]) = 4.7 + log ([0.01])/([0.090]) = 3.75 Isoelectric point of casein is tube 5. Question & Answers 1. The differences in pH value increases along the actual pH value. This is because the phosphate buffer has high buffering range in the pH...
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  • Acids and Bases
    endpoint of this titration. As a result, the concentration of the NaOH solution was found to be 0.124 M with a standard deviation of 0.004 M. In the second titration, the goal was to use both an acid’s formula weight and acid dissociation equilibrium constant (pKa) value to determine the identity of...
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  • Chem 3418 Organic Chemistry Laboratory I Acid Base Review
    . It is usually more convenient to use a logarithmic scale to handle these numbers. Accordingly, Ka values are transformed to pKa values using the formula pKa =-logKa Thus, the pKa for acetic acid becomes approximately 5. The pKa of phenol is 10. The pKa values of molecules can be used to classify...
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  • Chemistry 151 Weak Acid Titration
    sample and the weight of the sample we can determine the molar mass of that sample. Molar Mass is a unit with sub-units(g/mol) so by dividing the mass of the sample by the titrated moles we can determine the molar mass. To determine Ka values the equation pKa =-log Ka, along with the relationship...
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  • Determination of an Unknown Amino Acid from Titration
    Determination of An Unknown Amino Acid From Titration Abstract Experiment 11 used a titration curve to determine the identity of an unknown amino acid. The initial pH of the solution was 1.96, and the pKa's found experimentally were 2.0, 4.0, and 9.85. The accepted pKa values were found...
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  • Histidine Titration Lab
    4 Titration Curve of an Amino Acid pH Simple amino acid Acidic amino acid Basic amino acid 7 OH- equivalents Objectives: A) To determine the titration curve for an amino acid and B) to use this curve to estimate the pKa values of the ionizable groups of the amino acid and...
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  • Chem I: Identification of unknown acid
    Abstract After performing several experiments to determine the equivalent weight, melting point, and pKa values of the RCO2H, the unknown acid 251547-BS13 can be identified. Through experimentation, the equivalent weight of RCO2H was determined to be 83.06 g/mol. A 200-202 °C melting point...
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  • Synthesis of an Organic Acid
    determine the values at which x = 0, the equation was solved using the quadratic equation. A = 0.0036 B = -0.0984 C = 0.5926 X = 3.01 & 18.42 The only value that made sense is 3.01. So, this value was used as the pKa. From this point the amount of moles present was determined by raising 10...
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  • Structural and Electronic Effects Acids and Bases
    when describing acid strength to use “pKavalues than Ka values. 7 8 COMPARISON OF pKa and Ka VALUES pKa = - log Ka strong acids weak acids pKa -2 0 2 10-2 4 6 10-6 8 10 10-10 12 14 10-14 2 Ka 10 The smaller the value of the pKa the stronger the acid. We will use pKa to describe the...
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  • Physicochemical Properties of Local Anaesthetics
    mainly reflected by lipid solubility, protein binding, and vasodilator activity while onset of action is influenced by ionization, partition coefficient and dissociation constant (pKa values). As local anaesthetics are weak bases, they exist partly in a unionized form and partly in an ionized form...
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  • Acids and Bases Exercises
           Ka    B.  Ka       Kw    C.  Ka         D.  1       Ka    6.  Hydrochloric acid is a strong acid.  In a 0.010 moldm‐3 solution, calculate:  a)  pH  b)  hydroxide ion concentration        7       7.    Some weak acids and their pKa values are shown...
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  • Spectrophotometric Determination of the Acid Dissociation Constant of Methyl Red
    is also needed.Another method to determine the pKa value which was applied in this experiment is plotting pH against the logarithmic ratio of MR- and HMR Graph 1.5(in the appendix) .In this method,the pKa was directly determined by finding the equation of the line which is y = 0.6203x + 4.9414...
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  • Determine Pka of Ethanoic Acid
    Determining the pKa value for ethanoic acid Part 1: Determining the concentration of a solution of sodium hydroxide Method: 1. A clamp stand was set up to hold a burette, previously washed with distilled water and filled with sodium hydroxide solution of approximately 0.1moldm-3. The pH...
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  • Biochemistry Essay
    Aim: To verify the buffering capacity of a phosphate solution using a pH meter and construct a titration curve of an amino acid to determine the pka values of its ionisable groups to identitfy an unknown amino acid. Method: The ratio of [HPO42-] to [H2PO4-] required to produce buffer solutions...
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  • The Determination of Acid Constant Ka
    -Titration to determine the ka of Acetic Acid |pH=Pka |End-point | |4.04 |8.31...
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  • Synthesis of Asa
    graphical methods. Calculate the percentage purity of salicylic acid using the interpolated volume at the equivalence point of the second derivative plot of each trial. Determine the pKa of salicylic acid using the regular curve. Calculate the %difference between the experimental and theoretical pKa value...
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