Topics: Cuvette, Concentration, Colloid Pages: 8 (1429 words) Published: March 28, 2013
Particle size Zeta potential Molecular weight

The ultimate in desktop particle characterization


detailed specification from www.malvern.com/zetasizernano

Advanced technology made easy

The Zetasizer Nano ZS brings you the practicality of a maintenance-free system with the versatility of multi-parameter measurements in a single compact unit.

Particle Size
Non-invasive back scatter (NIBS®) technology takes particle sizing to new levels of sensitivity in the 0.6nm to 8.9 micron range. The new Zetasizer Nano ZS is the choice for the accurate, reliable and repeatable size analysis of particles and molecules in solution.

— Little or no dilution necessary — Colloid size and
size distribution

— Pharmaceuticals — Nanoparticles — Emulsions

Zeta potential
The new Zetasizer Nano ZS offers the highest ever sensitivity, accuracy and resolution for the measurement of zeta potential. This is achieved by a combination of laser Doppler velocimetry and phase analysis light scattering (PALS) in Malvern’s patented M3-PALS technique. Even samples of very low mobility can be analyzed and their mobility distributions calculated.

— Emulsion stability — Formulation stability — Water treatment — Pigment performance — Impurity determination

Chromatography flow-mode
Connect the Zetasizer Nano to your chromatography system for use as an absolute light scattering detector. Just position after the last detector in your SEC/ GPC system. The size and intensity are plotted in real time as the material is eluted from the column. Averages, peak positions and molecular weights of each peak are calculated automatically at the end of the measurement. — Only seconds to change from batch to flow-mode

Molecular weight
Using static light scattering (SLS) and the classical Debye plot, the molecular weight of random coiled polymers up to 5 x 105 Da as well as globular polymers and proteins up to 2 x 107 Da can be determined without the necessity for multi-angle measurements.

— No column calibration — Determine oligomeric state
of each eluted peak

— Quantify polydispersity — Compatible with
any SEC system

— Protein crystal screening — 2nd virial coefficient determination — Oligomer identification — Protein-melting point


The Zetasizer Nano ZS


Advanced technology made easy
— Choose from a range of cuvettes, volume as low as 12μL — Unique maintenance-free zeta potential cell — No alignment, calibration or maintenance required — Zeta potential and size can be measured in the same cell

How easy?

1 3 5

Power up the Zetasizer Nano ZS and launch the software
An automatic complete system self-check ensures that all components are ready for operation.

Fill the size or zeta potential cuvette
The low volume, folded capillary cell is the first ever for zeta potential which does not require cleaning. To eliminate cross-contamination; fill it, measure and, instead of cleaning, use a new one.

2 4

Load the cuvette
Simply insert the cuvette, close the lid and it’s ready to go.

Run the measurement
From the menu, select the standard operating procedure (SOP) you need or set your own conditions and click the ‘start’ button.

View the results
Predefined reports make reading, comparing and analyzing the results straightforward. Remove the cuvette and you are ready for the next sample.

That’s how easy
www.malvern.com The Zetasizer Nano ZS

Advanced technology made easy

Meeting your needs
At Malvern we strive for improvement in every instrument we design and produce. This process is made possible because we continually ask our customers what they think and what they need before turning those wishes into reality.

You asked for
Simple operation

We give you
Standard Operating Procedures (SOP) which ensures that measurements can be repeated using exactly the same parameters to give confidence in the result A comprehensive range of cells with volumes as small as...
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